OBO ID: CHEBI:91407

Term Name:	momelotinib		Search Ontology:
Synonyms:	CYT 11387 CYT 387 CYT-11387 CYT-387 CYT387 GS-0387 LM-1149 momelotinib momelotinibum N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide N-(cyanomethyl)-4-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)benzamide N-(cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide N-(cyanomethyl)-4-[2-[4-(4-morpholinyl)anilino]-4-pyrimidinyl]benzamide N-(cyanomethyl)-4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzamide
Definition:	A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis.
References:	CAS:1056634-68-4 DrugBank:DB11763 KEGG:D10315 LINCS:LSM-1141 PDBeChem:C87 PMID:19762238 PMID:21079613 PMID:23459451 PMID:25322686 PMID:25511866 PMID:27634203 PMID:27785927 PMID:28622623 PMID:28930494 PMID:28960447 PMID:29024542 PMID:29263442 PMID:29275119 PMID:29283448 PMID:29311136 PMID:29515114 PMID:30087028 PMID:30105668 PMID:31450973 PMID:31560729 Wikipedia:Momelotinib
Ontology:	Chebi