OBO ID: CHEBI:90881

Term Name:	irinotecan hydrochloride hydrate		Search Ontology:
Synonyms:	(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride--water (1/3) 1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium chloride--water (1/3) Camptosar CPT 11 CPT-11 Irinotecan hydrochloride irinotecan hydrochloride trihydrate irinotecan monohydrochloride trihydrate ONIVYDE U-101,440E
Definition:	A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
References:	CAS:136572-09-3 DrugBank:DB00762 KEGG:D01061 PMID:23984532 PMID:24190390 PMID:24424522 PMID:24585045 PMID:25233635 PMID:25248893 PMID:25750295 PMID:26309154 PMID:26352218 PMID:26526067 PMID:26531131 PMID:26540095 PMID:26656185 PMID:26706406 Reaxys:4838283 Wikipedia:Irinotecan
Ontology:	ChEBI  ( EBI )