OBO ID: CHEBI:90881
Term Name: irinotecan hydrochloride hydrate Search Ontology:
Synonyms:
  • (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride--water (1/3)
  • 1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium chloride--water (1/3)
  • Camptosar
  • CPT 11
  • CPT-11
  • Irinotecan hydrochloride
  • irinotecan hydrochloride trihydrate
  • irinotecan monohydrochloride trihydrate
  • ONIVYDE
  • U-101,440E
Definition: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
References:
Ontology: Chebi
PHENOTYPE No data available