OBO ID: CHEBI:87359

Term Name:	LY-411575		Search Ontology:
Synonyms:	LSN-411575 LY-411575 LY411575 N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N(1)-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
Definition:	A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.
References:	CAS:209984-57-6 PMID:14718585 PMID:15743924 PMID:17897827 PMID:19419556 PMID:22824752 PMID:23209290 PMID:23312516 PMID:23901284 PMID:24113577 PMID:24223998 PMID:24884926 PMID:25781991 Reaxys:10736555
Ontology:	ChEBI  ( EBI )