OBO ID: CHEBI:77823
Term Name: tilidine Search Ontology:
Synonyms:
  • ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • rac-ethyl (1R,2S)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • rac-ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • tilidina
  • tilidine
  • tilidinum
Definition: A racemate that is an equimolar mixture of the two trans diastereoisomers of ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, namely dextilidine and ent-dextilidine. It is used (commonly as the hydrochloride hemihydrate) as an opioid analgesic for the management of moderate to severe pain. A prodrug, it is metabolised in the body to nortilidine, which is responsible for the analgesic activity; virtually all of the opioid activity resides in the (1S,2R) isomer.
References:
Ontology: Chebi
PHENOTYPE No data available