OBO ID: CHEBI:71940

Term Name:	tadalafil		Search Ontology:
Synonyms:	(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE Adcirca Cialis tadalafil
Definition:	A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR-diastereomer). A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
References:	CAS:171596-29-5 DrugBank:DB00820 Drug_Central:2553 HMDB:HMDB0014958 KEGG:D02008 LINCS:LSM-4109 PDBeChem:CIA PMID:21056623 PMID:21680058 PMID:22014651 PMID:22328305 PMID:22494518 PMID:22776546 PMID:22816778 PMID:22971615 PMID:22982422 PMID:22996758 PMID:23033484 PMID:23072271 PMID:23118430 PMID:23140258 PMID:23190275 PMID:23216015 PMID:23219525 PMID:23234619 PMID:23312193 PMID:23346990 PMID:23347176 Patent:EP2107059 Patent:EP2238979 Patent:US2003229080 Patent:US2004157847 Patent:WO2005068464 Patent:WO2007113243 Patent:WO2009144734 Patent:WO2010049500 Patent:WO2012107549 Reaxys:9589181 Wikipedia:Tadalafil
Ontology:	ChEBI  ( EBI )