OBO ID: CHEBI:681569
Term Name: clofarabine Search Ontology:
Synonyms:
  • (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
  • CAFdA
  • Cl-F-Ara-A
  • clofarabina
  • clofarabine
  • clofarabinum
Definition: A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
References:
Ontology: Chebi
PHENOTYPE No data available