OBO ID: CHEBI:65484
Term Name: bevirimat Search Ontology:
Synonyms:
  • (3beta)-3-[(3-carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid
  • 3-O-(3',3'-dimethylsuccinyl) betulinic acid
  • bevirimat
  • bevirimatum
  • BVM
  • PA-457
Definition: A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.
References:
Ontology: Chebi
PHENOTYPE No data available