ZFIN ChEBI: benserazide

OBO ID: CHEBI:64187

Term Name:	benserazide		Search Ontology:
Synonyms:	2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide benserazida benserazide benserazidum DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide Ro 4-4602 Ro 44602
Definition:	A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
References:	CAS:322-35-0 Drug_Central:314 KEGG:D03082 LINCS:LSM-5097 PMID:12703659 PMID:22236652 Patent:BE619015 Patent:US3178476 Reaxys:3984490 Wikipedia:Benserazide
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	carbohydrazide catechols primary alcohol primary amino compound carbohydrazide catechols primary alcohol primary amino compound Show first 5 Terms
has_role:	antiparkinson drug dopaminergic agent EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor antiparkinson drug dopaminergic agent EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of:	benserazide(1+) benserazide(1+) Show first 5 Terms
is_conjugate_base_of:	benserazide(1+) benserazide(1+) Show first 5 Terms

PHENOTYPE No data available