OBO ID: CHEBI:64089
Term Name: vanoxerine Search Ontology:
Synonyms:
  • 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine
  • GBR 12909
  • GBR12909
  • vanoxerina
  • vanoxerine
  • vanoxerinum
Definition: An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
References:
Ontology: Chebi
PHENOTYPE No data available