Term Name: |
(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol |
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Search Ontology:
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Synonyms: |
- (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol
- A 77636
- A-77636
- A77636
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Definition: |
An isochromene that is 3,4-dihydroisochromene-5,6-diol bearing additional aminomethyl and 1-adamantyl substituents at positions 1 and 3 respectively (the 1R,3S-diastereomer). Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.
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References: |
- LINCS:LSM-20969
- Patent:EP870757
- Patent:US6057364
- Reaxys:5855679
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Ontology: |
ChEBI
(
EBI
)
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