OBO ID: CHEBI:64080
Term Name: (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol Search Ontology:
Synonyms:
  • (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol
  • A 77636
  • A-77636
  • A77636
Definition: An isochromene that is 3,4-dihydroisochromene-5,6-diol bearing additional aminomethyl and 1-adamantyl substituents at positions 1 and 3 respectively (the 1R,3S-diastereomer). Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.
References:
  • LINCS:LSM-20969
  • Patent:EP870757
  • Patent:US6057364
  • Reaxys:5855679
Ontology: ChEBI  ( EBI )
PHENOTYPE No data available