OBO ID: CHEBI:64069

Term Name:	SB 224289		Search Ontology:
Synonyms:	(1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone SB224289
Definition:	A member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid with the secondary amino group of 1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidine]. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.
References:	CAS:180083-23-2 PMID:18190518 PMID:19144744 PMID:19604677 PMID:20385119 PMID:20412834 PMID:21212522 PMID:21473863 PMID:21653728 Patent:US5972951
Ontology:	ChEBI  ( EBI )