OBO ID: CHEBI:63722
Term Name: pemetrexed disodium Search Ontology:
Synonyms:
  • disodium (2S)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
  • disodium N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate
Definition: An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
References:
  • CAS:150399-23-8
  • DrugBank:DB00642
  • KEGG:D03828
  • PMID:19137122
  • PMID:20209614
  • Patent:CN101411710
  • Patent:CN101560206
  • Patent:EP2301909
  • Patent:EP2334685
  • Patent:US2009181990
  • Patent:US2011124861
  • Patent:US2011196154
  • Patent:WO2010028105
  • Patent:WO2011019986
  • Patent:WO2011064256
  • Reaxys:8964395
Ontology: Chebi
PHENOTYPE No data available