OBO ID: CHEBI:63618

Term Name:	pravastatin		Search Ontology:
Synonyms:	(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid pravastatin pravastatin acid pravastatina pravastatine pravastatinum
Definition:	A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
References:	CAS:81093-37-0 DrugBank:DB00175 Drug_Central:2239 HMDB:HMDB0005022 KEGG:C01844 KEGG:D08410 KNApSAcK:C00000565 LINCS:LSM-3347 PMID:21749370 PMID:21851379 PMID:25264019 Reaxys:4825538 Wikipedia:Pravastatin
Ontology:	ChEBI  ( EBI )