OBO ID: CHEBI:63599

Term Name:	fludarabine phosphate		Search Ontology:
Synonyms:	2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine 2-Fluoro-ARA AMP 2-Fluoroadenine arabinoside 5'-monophosphate 2F-ara-AMP 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate) 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate FAMP Fludara Fludarabine 5'-monophosphate Fludarabine monophosphate
Definition:	A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
References:	CAS:75607-67-9 DrugBank:DB01073 Drug_Central:1189 KEGG:D01907 PMID:10720130 PMID:19283354 PMID:19567212 PMID:19862681 PMID:19915381 PMID:20215092 PMID:20467451 PMID:20514405 PMID:20686506 PMID:21296675 PMID:21725721 PMID:21736869 PMID:21909959 PMID:8204523 PMID:8528057 PMID:8651523 Patent:WO2010046917 Patent:WO2010133629 Reaxys:8167686 Wikipedia:Fludarabine
Ontology:	ChEBI  ( EBI )