OBO ID: CHEBI:63599
Term Name: fludarabine phosphate Search Ontology:
Synonyms:
  • 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-Fluoro-ARA AMP
  • 2-Fluoroadenine arabinoside 5'-monophosphate
  • 2F-ara-AMP
  • 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
  • 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
  • 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
  • FAMP
  • Fludara
  • Fludarabine 5'-monophosphate
  • Fludarabine monophosphate
Definition: A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
References:
Ontology: Chebi
PHENOTYPE No data available