OBO ID: CHEBI:48045
Term Name: salinosporamide A Search Ontology:
Synonyms:
  • (-)-salinosporamide A
  • (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
  • marizomib
  • marizomibum
  • ML 858
  • NPI 0052
  • NPI-0052
Definition: A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers.
References:
Ontology: ChEBI  ( EBI )
Relationships
is a type of:
has_role:
PHENOTYPE No data available

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