OBO ID: CHEBI:473990
Term Name: entecavir (anhydrous) Search Ontology:
Synonyms:
  • 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
  • entecavir
Definition: Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.
References:
  • Beilstein:7692760
  • CAS:142217-69-4
  • DrugBank:DB00442
  • Drug_Central:1019
  • KEGG:D07896
  • LINCS:LSM-5258
Ontology: ChEBI  ( EBI )
PHENOTYPE No data available