OBO ID: CHEBI:40009
Term Name: D-cycloserine Search Ontology:
Synonyms:
  • (+)-4-amino-3-isoxazolidinone
  • (+)-cycloserine
  • (4R)-4-aminoisoxazolidin-3-one
  • (R)-4-AMINO-ISOXAZOLIDIN-3-ONE
  • alpha-Cycloserine
  • cicloserina
  • cyclo-D-serine
  • cycloserine
  • cycloserinum
  • D-(+)-cycloserine
  • D-4-amino-3-isoxazolidinone
  • D-4-amino-3-isoxazolidone
  • D-Cycloserine
  • DCS
  • orientomycin
  • PA 94
  • PA-94
  • Ro-1-9213
  • Seromycin
Definition: A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).
References:
Ontology: Chebi
PHENOTYPE No data available