OBO ID: CHEBI:34967

Term Name:	rimonabant		Search Ontology:
Synonyms:	5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide A 281 Acomplia N-(1-piperidinyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxamide rimonabant rimonabantum SR 141716 SR141716 Zimulti
Definition:	A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.
References:	CAS:168273-06-1 Chemspider:94641 DrugBank:DB06155 Drug_Central:4150 HMDB:HMDB0015623 KEGG:C14319 KEGG:D05731 KNApSAcK:C00053749 LINCS:LSM-36994 PDBeChem:AY6 PMID:11881536 PMID:16934319 PMID:18290515 PMID:18479080 PMID:18654765 PMID:19490094 PMID:20067470 PMID:20828968 PMID:21470203 PMID:21740450 PMID:22182934 PMID:28429843 PMID:29407764 PMID:29797785 PMID:30077950 PMID:30300803 PMID:30556096 PMID:30682372 PMID:31522677 PMID:31898189 PMID:31981244 PMID:32085406 PMID:32417279 PMID:32463562 PMID:32512776 PMID:32781169 PMID:32885412 PMID:32904155 PMID:33121353 Wikipedia:Rimonabant
Ontology:	ChEBI  ( EBI )