OBO ID: CHEBI:3354
Term Name: candoxatrilat Search Ontology:
Synonyms:
  • 4-({1-[(S)-2-Carboxy-3-(2-methoxy-ethoxy)-propyl]-cyclopentanecarbonyl}-amino)-cyclohexanecarboxylic acid
  • candoxatrilat
  • candoxatrilate
  • cis-4-[({1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl}carbonyl)amino]cyclohexanecarboxylic acid
Definition: A dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP, neprilysin, EC 3.4.24.11), it is used as its 2,3-dihydro-1H-inden-5-yl ester prodrug in the treatment of chronic heart failure.
References:
  • Beilstein:8365079
  • CAS:123122-54-3
  • CAS:123898-42-0
  • DrugBank:DB00616
  • KEGG:C11721
  • KEGG:D03349
Ontology: ChEBI  ( EBI )
PHENOTYPE No data available