OBO ID: CHEBI:31539

Term Name:	epalrestat		Search Ontology:
Synonyms:	5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid 5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid epalrestat epalrestatum Kinedak ONO 2 Ono 2235 ONO-2 ONO-2235 {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
Definition:	A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
References:	CAS:82159-09-9 Drug_Central:1021 KEGG:D01688 PDBeChem:EPR PMID:19716319 PMID:22820572 PMID:23426701 PMID:24363998 PMID:3025043 Patent:EP47109 Patent:US4464382 Reaxys:4236712 Wikipedia:Epalrestat
Ontology:	ChEBI  ( EBI )