ZFIN ChEBI: benazepril

OBO ID: CHEBI:3011

Term Name:	benazepril		Search Ontology:
Synonyms:	1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R,R))- [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid benazepril benazeprilum
Definition:	A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
References:	CAS:86541-75-5 DrugBank:DB00542 Drug_Central:299 HMDB:HMDB0014682 KEGG:C06843 KEGG:D07499 LINCS:LSM-5609 MetaCyc:CPD-15329 PMID:25224804 PMID:25738503 PMID:25784709 PMID:25912588 Patent:EP72352 Patent:US4410520 Reaxys:4302258 Wikipedia:Benazepril
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	benzazepine dicarboxylic acid monoester ethyl ester lactam benzazepine dicarboxylic acid monoester ethyl ester lactam Show first 5 Terms
has_functional_parent:	benazeprilat benazeprilat Show first 5 Terms
has_role:	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor prodrug EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor prodrug Show first 5 Terms
inverse is_conjugate_acid_of:	benazepril(1+) benazepril(1+) Show first 5 Terms
is_conjugate_base_of:	benazepril(1+) benazepril(1+) Show first 5 Terms

PHENOTYPE No data available