OBO ID: CHEBI:28329

Term Name:	trioxsalen		Search Ontology:
Synonyms:	2',4,8-Trimethylpsoralen 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one 4,5',8-Trimethylpsoralen 4,8,5'-Trimethylpsoralen 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone Trimethylpsoralen trioxisaleno Trioxsalen Trioxysalen trioxysalene trioxysalenum
Definition:	7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
References:	Beilstein:221723 CAS:3902-71-4 DrugBank:DB04571 Drug_Central:2759 KEGG:C09314 KEGG:D01034 KNApSAcK:C00002502 LINCS:LSM-3223 Patent:US3201421 Wikipedia:Trioxsalen
Ontology:	ChEBI  ( EBI )