OBO ID: CHEBI:167629

Term Name:	JTE-607 dihydrochloride		Search Ontology:
Synonyms:	(-)-ethyl-N-[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride ethyl (2S)-2-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzamido}-3-phenylpropanoate dihydrochloride ethyl N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate dihydrochloride JTE 607 JTE 607 dihydrochloride JTE-607 JTE-607 .2HCl JTE-607 dihydrochloride N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Definition:	The dihydrochloride salt of JTE-607. It is a cytokine inhibitor which suppresses the production of proinflammatory cytokines such as interleukin (IL-1beta), IL-6, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF-alpha). It acts as a pro-drug which is cleaved by carboxylesterase 1 (CES1) to its active free acid form, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3).
References:	CAS:188791-09-5 PMID:10493164 PMID:12005207 PMID:12388363 PMID:15044056 PMID:15173729 PMID:15280441 PMID:16982331 PMID:18691526 PMID:20028380 PMID:21820084 PMID:31399191 PMID:31819276
Ontology:	ChEBI  ( EBI )