OBO ID: CHEBI:156258

Term Name:	enrasentan		Search Ontology:
Synonyms:	(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid (1S,2R,3S)-3-(2-(2-hydroxyethoxy)-4-methoxyphenyl)-1-(3,4-(methylenedioxy)phenyl)-5-propoxy-2-indancarboxylic acid enrasentan enrasentanum SB 217242 SB-217242 SB217242
Definition:	A member of the class of indanes that is 2,3-dihydro-1H-indene which is substituted by a 1,3-benzodioxol-5-yl group, carboxy group, 2-(2-hydroxyethoxy)-4-methoxyphenyl group and a propoxy group at positions 1S, 2R, 3S and 5, respectively. It is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor. The drug was being developed by GSK for the treatment of congestive heart failure and pulmonary hypertension (clinical trials discontinued).
References:	CAS:167256-08-8 DrugBank:DB06460 PMID:10208832 PMID:10610275 PMID:11078416 PMID:11588531 PMID:11904522 PMID:12376360 PMID:12595914 PMID:16339819 PMID:8587428 PMID:8632328 PMID:9399985 PMID:9595469 PMID:9595510 PMID:9631875 PMID:9988883
Ontology:	ChEBI  ( EBI )