OBO ID: CHEBI:145994

Term Name:	remdesivir		Search Ontology:
Synonyms:	(2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate GS 5734 GS-5734 GS5734 remdesivir remdesivirum
Definition:	A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.
References:	CAS:1809249-37-3 DrugBank:DB14761 KEGG:D11472 PMCID:PMC5630887 PMID:26934220 PMID:28124907 PMID:28262699 PMID:28659436 PMID:29511076 PMID:30275474 PMID:30987343 PMID:31142680 PMID:31233808 PMID:31924756 PMID:32020029 PMID:32054787 PMID:32094225 PMID:32145386 PMID:32147516 PMID:32152082 Wikipedia:Remdesivir
Ontology:	ChEBI  ( EBI )