OBO ID: CHEBI:145536

Term Name:	motixafortide		Search Ontology:
Synonyms:	(3S,6S,9S,12R,17R,20S,23S,26S,29R,34aS)-26,29-bis(4-aminobutyl)-N-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]-17-{[(2S)-2-{[(2S)-5-carbamimidamido-2-{[(2S)-5-carbamimidamido-2-(4-fluorobenzamido)pentanoyl]amino}pentanoyl]amino}-3-(naphthalen-2-yl)pr 4F-benzoyl-TN14003 BKT 140 BKT-140 BKT140 BL 8040 BL-8040 BL8040 motixafortida motixafortide motixafortidum TF 14016 TF-14016 TF14016 TN-14003
Definition:	A heterodetic cyclic peptide that has antineoplastic activity. It is a CXC chemokine receptor 4 (CXCR4) antagonist with an IC50 value of 0.8 nM and is currently under clinical investigation for the treatment of hematological malignancies, solid tumors, and stem cell mobilization. It was granted orphan drug designation by the FDA for the treatment of pancreatic cancer in 2019.
References:	CAS:664334-36-5 DrugBank:DB14939 KEGG:D12281 PMID:12935890 PMID:15207725 PMID:17525235 PMID:19322207 PMID:19584281 PMID:21138752 PMID:22925564 PMID:22992418 PMID:23637121 PMID:23906028 PMID:24246358 PMID:24502926 PMID:28280274 PMID:28835380 Wikipedia:Motixafortide
Ontology:	ChEBI  ( EBI )