OBO ID: CHEBI:145371

Term Name:	binimetinib		Search Ontology:
Synonyms:	5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide ARRY 162 ARRY 438162 ARRY-162 ARRY-438162 binimetinib binimetinibum MEK-162 MEK162 Mektovi N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide NVP-MEK162
Definition:	A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.
References:	CAS:606143-89-9 DrugBank:DB11967 KEGG:D10604 LINCS:LSM-45640 PMCID:PMC6012544 PMID:23414587 PMID:27071922 PMID:28152546 PMID:28412197 PMID:28587477 PMID:28851243 PMID:29785570 PMID:29946554 PMID:30117021 PMID:30635233 PMID:30648436 PMID:30652516 PMID:30956763 PMID:31050693 PMID:31129802 PMID:31213500 PMID:31312030 PMID:31395751 PMID:31436845 PMID:31437754 PMID:31631932 Wikipedia:Binimetinib
Ontology:	ChEBI  ( EBI )