ZFIN ChEBI: 6-diazo-5-oxo-L-norleucine

OBO ID: CHEBI:138889

Term Name:	6-diazo-5-oxo-L-norleucine		Search Ontology:
Synonyms:	(S)-2-amino-6-diazo-5-oxocaproic acid 6-diazo-5-oxo-L-norleucine diazooxonorleucine L-DON
Definition:	A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes.
References:	Beilstein:1725815 CAS:157-03-9 MetaCyc:CPD0-1627 PMID:1412455 PMID:2108451 PMID:25584882 PMID:26425550 PMID:27489275 PMID:27560860 PMID:28454342 PMID:28552037 PMID:28759224 PMID:909432 Pubchem:24893639 Wikipedia:6-Diazo-5-oxo-L-norleucine
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	diazo compound ketone non-proteinogenic L-alpha-amino acid diazo compound ketone non-proteinogenic L-alpha-amino acid Show first 5 Terms
has_role:	analgesic antibacterial agent antimetabolite antineoplastic agent antiviral agent ... Show All 16 Terms analgesic antibacterial agent antimetabolite antineoplastic agent antiviral agent apoptosis inducer bacterial metabolite EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor EC 3.5.1.2 (glutaminase) inhibitor EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor glutamine antagonist Show first 5 Terms
inverse is_tautomer_of:	6-diazo-5-oxo-L-norleucine zwitterion 6-diazo-5-oxo-L-norleucine zwitterion Show first 5 Terms
is_tautomer_of:	6-diazo-5-oxo-L-norleucine zwitterion 6-diazo-5-oxo-L-norleucine zwitterion Show first 5 Terms

PHENOTYPE No data available