OBO ID: CHEBI:138435
Term Name: bis(7)-tacrine Search Ontology:
Synonyms:
  • B7T
  • bis(7)-tetrahydroaminacrine
  • heptylene-bis(tacrine)
  • N,N'-bis(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine
  • N,N'-di(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine
Definition: A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells.
References:
Ontology: Chebi
PHENOTYPE No data available