Relationships

has subtype:

activation of NF-kappaB-inducing kinase activity behavior biological adhesion biological phase biological regulation biomineralization carbohydrate utilization carbon utilization cell aggregation cell killing cell population proliferation cellular component organization or biogenesis cellular process detoxification developmental process growth immune system process inhibition of neuroepithelial cell differentiation localization locomotion metabolic process modulation of chemical synaptic transmission modulation of symbiont germ tube hook structure formation on or near host modulation of zoospore movement on or near host multi-organism process multicellular organismal process negative regulation of 'de novo' NAD biosynthetic process from tryptophan negative regulation of (+)-kotanin biosynthetic process negative regulation of (1->3)-beta-D-glucan biosynthetic process negative regulation of (R)-carnitine transmembrane transport negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process negative regulation of (Z)-nonadeca-1,14-diene metabolic process negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process negative regulation of 1-phosphatidylinositol 4-kinase activity negative regulation of 1-phosphatidylinositol-3-kinase activity negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity negative regulation of 3'-UTR-mediated mRNA stabilization negative regulation of 17-methylnonadec-1-ene biosynthetic process negative regulation of 17-methylnonadec-1-ene metabolic process negative regulation of 18-methylnonadec-1-ene biosynthetic process negative regulation of 18-methylnonadec-1-ene metabolic process negative regulation of [2Fe-2S] cluster assembly negative regulation of [4Fe-4S] cluster assembly negative regulation of abscisic acid biosynthetic process negative regulation of abscisic acid-activated signaling pathway negative regulation of acetate catabolic process negative regulation of acetylcholine metabolic process negative regulation of acetylcholine secretion, neurotransmission negative regulation of acetylcholine uptake negative regulation of acetylcholine-gated cation channel activity negative regulation of acid-sensing ion channel activity negative regulation of acinar cell proliferation negative regulation of aconitate hydratase activity negative regulation of acrosome reaction negative regulation of actin binding negative regulation of actin cortical patch assembly negative regulation of actin cytoskeleton reorganization negative regulation of actin filament binding negative regulation of actin filament bundle assembly negative regulation of actin filament depolymerization negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly negative regulation of actin filament polymerization negative regulation of actin filament severing negative regulation of actin nucleation negative regulation of actin-dependent ATPase activity negative regulation of action potential negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of activated T cell autonomous cell death negative regulation of activated T cell proliferation negative regulation of activation of Janus kinase activity negative regulation of activation of membrane attack complex negative regulation of activation-induced cell death of T cells negative regulation of activin receptor signaling pathway negative regulation of activin secretion negative regulation of actomyosin contractile ring localization negative regulation of acute inflammatory response negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus negative regulation of acylglycerol transport negative regulation of adaptive immune effector response negative regulation of adaptive immune memory response negative regulation of adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of adenosine receptor signaling pathway negative regulation of adenosine transport negative regulation of adenylate cyclase activity negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway negative regulation of adherens junction organization negative regulation of adhesion of symbiont to host epithelial cell negative regulation of adiponectin secretion negative regulation of adipose tissue development negative regulation of adult chitin-containing cuticle pigmentation negative regulation of adult salivary gland boundary specification negative regulation of advanced glycation end-product receptor activity negative regulation of aeciospore formation negative regulation of aecium development negative regulation of aflatoxin biosynthetic process negative regulation of age-related resistance negative regulation of aggregation involved in sorocarp development negative regulation of aggrephagy negative regulation of alcohol biosynthetic process negative regulation of aldosterone biosynthetic process negative regulation of aldosterone metabolic process negative regulation of aldosterone secretion negative regulation of alkaline phosphatase activity negative regulation of alkane biosynthetic process negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity negative regulation of alpha-(1->3)-fucosyltransferase activity negative regulation of alpha-beta T cell activation negative regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell proliferation negative regulation of amacrine cell differentiation negative regulation of amine transport negative regulation of amino acid transport negative regulation of amino acid uptake involved in synaptic transmission negative regulation of aminoacyl-tRNA ligase activity negative regulation of ammonia assimilation cycle negative regulation of amniotic stem cell differentiation negative regulation of amoeboid sperm motility negative regulation of AMPA glutamate receptor clustering negative regulation of AMPA receptor activity negative regulation of amyloid fibril formation negative regulation of amyloid precursor protein biosynthetic process negative regulation of amyloid precursor protein catabolic process negative regulation of amyloid-beta clearance negative regulation of amyloid-beta formation negative regulation of amylopectin catabolic process negative regulation of amylopectin metabolic process negative regulation of anaphase-promoting complex-dependent catabolic process negative regulation of androgen biosynthetic process negative regulation of androgen receptor signaling pathway negative regulation of androgen secretion negative regulation of androst-4-ene-3,17-dione biosynthetic process negative regulation of androstenedione secretion negative regulation of angiogenesis negative regulation of angiotensin-activated signaling pathway negative regulation of anion channel activity negative regulation of anion transmembrane transport negative regulation of anion transport negative regulation of anoikis negative regulation of anterior head development negative regulation of anterior/posterior axon guidance negative regulation of anterograde axonal transport of mitochondrion negative regulation of anterograde dense core granule transport negative regulation of anterograde synaptic vesicle transport negative regulation of anther dehiscence negative regulation of anthocyanin biosynthetic process negative regulation of anthocyanin catabolic process negative regulation of anthocyanin metabolic process negative regulation of anti-Mullerian hormone signaling pathway negative regulation of antibacterial peptide biosynthetic process negative regulation of antibacterial peptide production negative regulation of antibacterial peptide secretion negative regulation of antibody-dependent cellular cytotoxicity negative regulation of antifungal innate immune response negative regulation of antifungal peptide biosynthetic process negative regulation of antifungal peptide production negative regulation of antifungal peptide secretion negative regulation of antigen processing and presentation negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib negative regulation of antigen processing and presentation of peptide antigen negative regulation of antigen processing and presentation of peptide antigen via MHC class I negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib negative regulation of antigen processing and presentation of peptide antigen via MHC class II negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II negative regulation of antigen processing and presentation via MHC class Ib negative regulation of antigen receptor-mediated signaling pathway negative regulation of antimicrobial humoral response negative regulation of antimicrobial peptide biosynthetic process negative regulation of antimicrobial peptide production negative regulation of antimicrobial peptide secretion negative regulation of antipodal cell differentiation negative regulation of antisense RNA transcription negative regulation of aorta morphogenesis negative regulation of aortic smooth muscle cell differentiation negative regulation of apical ectodermal ridge formation negative regulation of aplanospore formation negative regulation of apolipoprotein A-I-mediated signaling pathway negative regulation of apolipoprotein binding negative regulation of apoptosome assembly negative regulation of apoptotic cell clearance negative regulation of apoptotic DNA fragmentation negative regulation of apoptotic process negative regulation of apoptotic process in bone marrow cell negative regulation of apoptotic process involved in development negative regulation of apoptotic process involved in metanephric collecting duct development negative regulation of apoptotic process involved in metanephric nephron tubule development negative regulation of apoptotic process involved in morphogenesis negative regulation of apoptotic process involved in outflow tract morphogenesis negative regulation of apoptotic signaling pathway negative regulation of appressorium formation on or near host negative regulation of appressorium initiation on or near host negative regulation of appressorium maturation on or near host negative regulation of arabinoxylan-containing compound catabolic process negative regulation of arachidonic acid secretion negative regulation of ARF protein signal transduction negative regulation of arginine catabolic process negative regulation of Arp2/3 complex-mediated actin nucleation negative regulation of artery morphogenesis negative regulation of artery smooth muscle contraction negative regulation of arugosin biosynthetic process negative regulation of ascospore formation negative regulation of ascus development negative regulation of asexual reproduction negative regulation of asexual sporulation resulting in formation of a cellular spore negative regulation of aspartate secretion negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of aspartic-type peptidase activity negative regulation of asperfuranone biosynthetic process negative regulation of asperthecin biosynthetic process negative regulation of astral microtubule depolymerization negative regulation of astrocyte activation negative regulation of astrocyte chemotaxis negative regulation of astrocyte differentiation negative regulation of asymmetric cell division negative regulation of asymmetric protein localization involved in cell fate determination negative regulation of ATF6-mediated unfolded protein response negative regulation of Atg1/ULK1 kinase complex assembly negative regulation of ATP biosynthetic process negative regulation of ATP citrate synthase activity negative regulation of ATP metabolic process negative regulation of ATP-dependent microtubule motor activity, minus-end-directed negative regulation of ATP-dependent microtubule motor activity, plus-end-directed negative regulation of ATP:ADP antiporter activity negative regulation of ATPase activity negative regulation of ATPase-coupled calcium transmembrane transporter activity negative regulation of atrial cardiac muscle cell action potential negative regulation of atrichoblast fate specification negative regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of attachment of spindle microtubules to kinetochore negative regulation of auditory receptor cell fate specification negative regulation of austinol biosynthetic process negative regulation of autophagic cell death negative regulation of autophagosome assembly negative regulation of autophagosome maturation negative regulation of autophagy negative regulation of autophagy of mitochondrion negative regulation of auxin mediated signaling pathway negative regulation of auxin metabolic process negative regulation of AV node cell action potential negative regulation of axial mesodermal cell fate determination negative regulation of axial mesodermal cell fate specification negative regulation of axo-dendritic protein transport negative regulation of axon extension negative regulation of axon extension involved in axon guidance negative regulation of axon extension involved in regeneration negative regulation of axon guidance negative regulation of axon regeneration negative regulation of axonemal microtubule depolymerization negative regulation of axonogenesis negative regulation of B cell activation negative regulation of B cell anergy negative regulation of B cell antigen processing and presentation negative regulation of B cell apoptotic process negative regulation of B cell chemotaxis negative regulation of B cell cytokine production negative regulation of B cell deletion negative regulation of B cell differentiation negative regulation of B cell mediated immunity negative regulation of B cell proliferation negative regulation of B cell receptor signaling pathway negative regulation of B cell tolerance induction negative regulation of B-1 B cell differentiation negative regulation of backward locomotion negative regulation of bacterial-type flagellum assembly negative regulation of bacterial-type flagellum-dependent cell motility negative regulation of barbed-end actin filament capping negative regulation of base-excision repair negative regulation of basement membrane assembly involved in embryonic body morphogenesis negative regulation of basidiospore formation negative regulation of basidium development negative regulation of basophil degranulation negative regulation of basophil differentiation negative regulation of behavior negative regulation of behavioral fear response negative regulation of beta 2 integrin biosynthetic process negative regulation of beta-catenin-TCF complex assembly negative regulation of beta-galactosidase activity negative regulation of beta1-adrenergic receptor activity negative regulation of bicellular tight junction assembly negative regulation of bicoid mRNA localization negative regulation of bile acid biosynthetic process negative regulation of bile acid metabolic process negative regulation of bile acid secretion negative regulation of binding negative regulation of binding of sperm to zona pellucida negative regulation of biological process negative regulation of bioluminescence negative regulation of biomineral tissue development negative regulation of biosynthetic process negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria negative regulation of bipolar cell growth negative regulation of bleb assembly negative regulation of blood circulation negative regulation of blood coagulation negative regulation of blood coagulation, common pathway negative regulation of blood coagulation, extrinsic pathway negative regulation of blood coagulation, intrinsic pathway negative regulation of blood microparticle formation negative regulation of blood vessel endothelial cell differentiation negative regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of blood vessel morphogenesis negative regulation of blood vessel remodeling negative regulation of BMP secretion negative regulation of BMP signaling pathway negative regulation of BMP signaling pathway by negative regulation of BMP secretion negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of bone development negative regulation of bone mineralization negative regulation of bone mineralization involved in bone maturation negative regulation of bone remodeling negative regulation of bone resorption negative regulation of bone trabecula formation negative regulation of border follicle cell delamination negative regulation of border follicle cell migration negative regulation of brain-derived neurotrophic factor receptor signaling pathway negative regulation of brain-derived neurotrophic factor-activated receptor activity negative regulation of branch elongation involved in ureteric bud branching negative regulation of branching involved in lung morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of branching morphogenesis of a nerve negative regulation of branchiomeric skeletal muscle development negative regulation of brassinosteroid biosynthetic process negative regulation of brassinosteroid mediated signaling pathway negative regulation of brevianamide F biosynthetic process negative regulation of brown fat cell differentiation negative regulation of brown fat cell proliferation negative regulation of bud outgrowth involved in lung branching negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA negative regulation of butyryl-CoA catabolic process to butanol negative regulation of butyryl-CoA catabolic process to butyrate negative regulation of C-C chemokine binding negative regulation of C-C chemokine receptor CCR7 signaling pathway negative regulation of c-di-GMP signaling negative regulation of calcidiol 1-monooxygenase activity negative regulation of calcineurin-NFAT signaling cascade negative regulation of calcitonin secretion negative regulation of calcium ion binding negative regulation of calcium ion export across plasma membrane negative regulation of calcium ion import negative regulation of calcium ion import into sarcoplasmic reticulum negative regulation of calcium ion transmembrane transport negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of calcium ion transmembrane transporter activity negative regulation of calcium ion transport negative regulation of calcium ion transport into cytosol negative regulation of calcium ion-dependent exocytosis negative regulation of calcium ion-dependent exocytosis of neurotransmitter negative regulation of calcium-dependent ATPase activity negative regulation of calcium-dependent cell-cell adhesion negative regulation of calcium-independent cell-cell adhesion negative regulation of calcium-mediated signaling negative regulation of calcium:sodium antiporter activity negative regulation of CAMKK-AMPK signaling cascade negative regulation of cAMP-dependent protein kinase activity negative regulation of cAMP-mediated signaling negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of canonical Wnt signaling pathway involved in heart development negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of cap-dependent translational initiation negative regulation of cap-independent translational initiation negative regulation of capsule organization negative regulation of carbohydrate metabolic process negative regulation of cardiac cell fate specification negative regulation of cardiac chamber formation negative regulation of cardiac chamber morphogenesis negative regulation of cardiac conduction negative regulation of cardiac muscle adaptation negative regulation of cardiac muscle cell apoptotic process negative regulation of cardiac muscle cell differentiation negative regulation of cardiac muscle cell myoblast differentiation negative regulation of cardiac muscle cell proliferation negative regulation of cardiac muscle contraction negative regulation of cardiac muscle fiber development negative regulation of cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of cardiac muscle myoblast proliferation negative regulation of cardiac muscle tissue development negative regulation of cardiac muscle tissue growth negative regulation of cardiac muscle tissue regeneration negative regulation of cardiac myofibril assembly negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis negative regulation of cardiac vascular smooth muscle cell differentiation negative regulation of cardiac ventricle development negative regulation of cardiac ventricle formation negative regulation of cardioblast cell fate specification negative regulation of cardioblast differentiation negative regulation of cardioblast proliferation negative regulation of cardiocyte differentiation negative regulation of cardiolipin metabolic process negative regulation of cargo loading into COPII-coated vesicle negative regulation of carotenoid biosynthetic process negative regulation of cartilage condensation negative regulation of cartilage development negative regulation of catabolic process negative regulation of catalase activity negative regulation of catalytic activity negative regulation of catecholamine metabolic process negative regulation of catecholamine secretion negative regulation of catecholamine uptake involved in synaptic transmission negative regulation of cation channel activity negative regulation of cation transmembrane transport negative regulation of caveolin-mediated endocytosis negative regulation of CD4 biosynthetic process negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell costimulation negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation negative regulation of CD8-positive, alpha-beta T cell activation negative regulation of CD8-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell extravasation negative regulation of CD8-positive, alpha-beta T cell proliferation negative regulation of CD40 signaling pathway negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell adhesion involved in single-species biofilm formation negative regulation of cell adhesion involved in sprouting angiogenesis negative regulation of cell adhesion mediated by integrin negative regulation of cell adhesion molecule production negative regulation of cell aging negative regulation of cell budding negative regulation of cell chemotaxis to fibroblast growth factor negative regulation of cell communication negative regulation of cell communication by chemical coupling negative regulation of cell communication by electrical coupling negative regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of cell cycle negative regulation of cell cycle arrest negative regulation of cell cycle checkpoint negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle G2/M phase transition negative regulation of cell cycle phase transition negative regulation of cell cycle process negative regulation of cell cycle switching, mitotic to meiotic cell cycle negative regulation of cell death negative regulation of cell development negative regulation of cell differentiation negative regulation of cell differentiation involved in embryonic placenta development negative regulation of cell division negative regulation of cell fate commitment negative regulation of cell fate specification negative regulation of cell growth negative regulation of cell growth involved in cardiac muscle cell development negative regulation of cell junction assembly negative regulation of cell killing negative regulation of cell maturation negative regulation of cell migration negative regulation of cell migration involved in sprouting angiogenesis negative regulation of cell morphogenesis involved in differentiation negative regulation of cell motility negative regulation of cell motility involved in cerebral cortex radial glia guided migration negative regulation of cell population proliferation negative regulation of cell projection organization negative regulation of cell proliferation in bone marrow negative regulation of cell proliferation in dorsal spinal cord negative regulation of cell proliferation in midbrain negative regulation of cell proliferation involved in compound eye morphogenesis negative regulation of cell proliferation involved in heart morphogenesis negative regulation of cell proliferation involved in heart valve morphogenesis negative regulation of cell proliferation involved in kidney development negative regulation of cell proliferation involved in mesonephros development negative regulation of cell septum assembly negative regulation of cell wall organization or biogenesis negative regulation of cell wall polysaccharide catabolic process negative regulation of cell-cell adhesion negative regulation of cell-cell adhesion mediated by cadherin negative regulation of cell-cell adhesion mediated by integrin negative regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion negative regulation of cellobiose catabolic process negative regulation of cellobiose metabolic process negative regulation of cellodextrin catabolic process negative regulation of cellodextrin metabolic process negative regulation of cellooligosaccharide catabolic process negative regulation of cellooligosaccharide metabolic process negative regulation of cellotriose catabolic process negative regulation of cellotriose metabolic process negative regulation of cellotriose transport negative regulation of cellular alcohol catabolic process negative regulation of cellular amide catabolic process negative regulation of cellular amide metabolic process negative regulation of cellular amine catabolic process negative regulation of cellular amine metabolic process negative regulation of cellular amino acid biosynthetic process negative regulation of cellular amino acid metabolic process negative regulation of cellular biosynthetic process negative regulation of cellular carbohydrate metabolic process negative regulation of cellular catabolic process negative regulation of cellular component movement negative regulation of cellular component organization negative regulation of cellular defense response negative regulation of cellular extravasation negative regulation of cellular glucuronidation negative regulation of cellular hyperosmotic salinity response negative regulation of cellular macromolecule biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular organofluorine metabolic process negative regulation of cellular organohalogen metabolic process negative regulation of cellular pH reduction negative regulation of cellular process negative regulation of cellular protein catabolic process negative regulation of cellular protein localization negative regulation of cellular protein metabolic process negative regulation of cellular respiration negative regulation of cellular response to alkaline pH negative regulation of cellular response to amino acid starvation negative regulation of cellular response to caffeine negative regulation of cellular response to drug negative regulation of cellular response to gamma radiation negative regulation of cellular response to growth factor stimulus negative regulation of cellular response to heat negative regulation of cellular response to hepatocyte growth factor stimulus negative regulation of cellular response to hypoxia negative regulation of cellular response to insulin stimulus negative regulation of cellular response to iron ion starvation negative regulation of cellular response to macrophage colony-stimulating factor stimulus negative regulation of cellular response to manganese ion negative regulation of cellular response to nitrogen starvation negative regulation of cellular response to oxidative stress negative regulation of cellular response to oxidopamine negative regulation of cellular response to testosterone stimulus negative regulation of cellular response to thapsigargin negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of cellular response to tunicamycin negative regulation of cellular response to vascular endothelial growth factor stimulus negative regulation of cellular response to very-low-density lipoprotein particle stimulus negative regulation of cellular response to X-ray negative regulation of cellular senescence negative regulation of cellulose biosynthetic process negative regulation of cellulose catabolic process negative regulation of cellulosome assembly negative regulation of CENP-A containing nucleosome assembly negative regulation of central B cell anergy negative regulation of central B cell deletion negative regulation of central B cell tolerance induction negative regulation of central tolerance induction negative regulation of centriole elongation negative regulation of centriole replication negative regulation of centriole-centriole cohesion negative regulation of centrosome cycle negative regulation of centrosome duplication negative regulation of ceramide biosynthetic process negative regulation of cerebellar granule cell precursor proliferation negative regulation of cerebellar neuron development negative regulation of cGMP-mediated signaling negative regulation of chanoclavine-I aldehyde biosynthetic process negative regulation of chanoclavine-I biosynthetic process negative regulation of chaperone-mediated autophagy negative regulation of chaperone-mediated protein folding negative regulation of chemokine (C-C motif) ligand 1 production negative regulation of chemokine (C-C motif) ligand 2 secretion negative regulation of chemokine (C-C motif) ligand 4 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of chemokine (C-C motif) ligand 6 production negative regulation of chemokine (C-C motif) ligand 6 secretion negative regulation of chemokine (C-C motif) ligand 20 production negative regulation of chemokine (C-X-C motif) ligand 1 production negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of chemokine (C-X-C motif) ligand 9 production negative regulation of chemokine activity negative regulation of chemokine biosynthetic process negative regulation of chemokine production negative regulation of chemokine secretion negative regulation of chemokine-mediated signaling pathway negative regulation of chemokinesis negative regulation of chemorepellent activity negative regulation of chemotaxis negative regulation of chemotaxis to arachidonic acid negative regulation of chitin-based cuticle tanning negative regulation of chloride transport negative regulation of chlorophyll biosynthetic process negative regulation of chlorophyll catabolic process negative regulation of chloroplast fission negative regulation of cholangiocyte apoptotic process negative regulation of cholangiocyte proliferation negative regulation of cholesterol biosynthetic process negative regulation of cholesterol efflux negative regulation of cholesterol import negative regulation of cholesterol metabolic process negative regulation of cholesterol storage negative regulation of cholesterol transport negative regulation of cholesterol transporter activity negative regulation of choline O-acetyltransferase activity negative regulation of chondrocyte development negative regulation of chondrocyte differentiation negative regulation of chondrocyte hypertrophy negative regulation of chondrocyte proliferation negative regulation of chorionic trophoblast cell proliferation negative regulation of chromatin assembly or disassembly negative regulation of chromatin binding negative regulation of chromatin organization negative regulation of chromatin silencing negative regulation of chromatin silencing at rDNA negative regulation of chromatin silencing at silent mating-type cassette negative regulation of chromatin silencing at telomere negative regulation of chromatin silencing by small RNA negative regulation of chromatin silencing involved in replicative cell aging negative regulation of chromatin-mediated maintenance of transcription negative regulation of chromosome condensation negative regulation of chromosome organization negative regulation of chromosome segregation negative regulation of chromosome separation negative regulation of chronic inflammatory response negative regulation of chronic inflammatory response to antigenic stimulus negative regulation of chronic inflammatory response to non-antigenic stimulus negative regulation of cilium assembly negative regulation of cilium movement negative regulation of cilium-dependent cell motility negative regulation of circadian rhythm negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of circadian sleep/wake cycle, REM sleep negative regulation of circadian sleep/wake cycle, sleep negative regulation of circadian sleep/wake cycle, wakefulness negative regulation of citrulline biosynthetic process negative regulation of clathrin coat assembly negative regulation of clathrin-coated pit assembly negative regulation of clathrin-dependent endocytosis negative regulation of cleistothecium development negative regulation of coagulation negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process negative regulation of coenzyme metabolic process negative regulation of cofactor metabolic process negative regulation of coflocculation via protein-carbohydrate interaction negative regulation of cohesin loading negative regulation of cohesin unloading negative regulation of cold-induced thermogenesis negative regulation of collagen binding negative regulation of collagen biosynthetic process negative regulation of collagen catabolic process negative regulation of collagen fibril organization negative regulation of collagen metabolic process negative regulation of collateral sprouting negative regulation of collateral sprouting in absence of injury negative regulation of collateral sprouting of injured axon negative regulation of collateral sprouting of intact axon in response to injury negative regulation of collecting lymphatic vessel constriction negative regulation of colon smooth muscle contraction negative regulation of complement activation negative regulation of complement activation, alternative pathway negative regulation of complement activation, classical pathway negative regulation of complement activation, lectin pathway negative regulation of complement-dependent cytotoxicity negative regulation of compound eye cone cell fate specification negative regulation of compound eye photoreceptor development negative regulation of compound eye pigmentation negative regulation of compound eye retinal cell apoptotic process negative regulation of compound eye retinal cell programmed cell death negative regulation of conidiophore development negative regulation of conidiophore stalk development negative regulation of conidium formation negative regulation of conjugation negative regulation of conjugation with cellular fusion negative regulation of connective tissue growth factor biosynthetic process negative regulation of connective tissue growth factor production negative regulation of connective tissue replacement negative regulation of connective tissue replacement involved in inflammatory response wound healing negative regulation of constitutive secretory pathway negative regulation of convergent extension involved in axis elongation negative regulation of convergent extension involved in gastrulation negative regulation of convergent extension involved in neural plate elongation negative regulation of convergent extension involved in notochord morphogenesis negative regulation of convergent extension involved in rhombomere morphogenesis negative regulation of convergent extension involved in somitogenesis negative regulation of copper ion transmembrane transport negative regulation of cordyol C biosynthetic process negative regulation of core promoter binding negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway negative regulation of cornification negative regulation of corticosteroid hormone secretion negative regulation of corticosterone secretion negative regulation of corticotropin secretion negative regulation of corticotropin-releasing hormone receptor activity negative regulation of corticotropin-releasing hormone secretion negative regulation of cortisol biosynthetic process negative regulation of cortisol secretion negative regulation of creatine transmembrane transporter activity negative regulation of cristae formation negative regulation of crystal cell differentiation negative regulation of cumulus cell differentiation negative regulation of cuticle pigmentation negative regulation of cutin biosynthetic process negative regulation of cyanophore differentiation negative regulation of cyclase activity negative regulation of cyclic nucleotide-gated ion channel activity negative regulation of cyclic-nucleotide phosphodiesterase activity negative regulation of cyclin-dependent protein kinase activity negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cyclodextrin catabolic process negative regulation of cyclodextrin metabolic process negative regulation of cystathionine beta-synthase activity negative regulation of cysteine metabolic process negative regulation of cysteine-type endopeptidase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis negative regulation of cytochrome-c oxidase activity negative regulation of cytokine activity negative regulation of cytokine biosynthetic process negative regulation of cytokine biosynthetic process involved in immune response negative regulation of cytokine production negative regulation of cytokine production involved in immune response negative regulation of cytokine production involved in inflammatory response negative regulation of cytokine secretion negative regulation of cytokine secretion involved in immune response negative regulation of cytokine-mediated signaling pathway negative regulation of cytokinesis negative regulation of cytokinesis, actomyosin contractile ring assembly negative regulation of cytokinesis, site selection negative regulation of cytokinin dehydrogenase activity negative regulation of cytokinin-activated signaling pathway negative regulation of cytolysis negative regulation of cytolysis by symbiont of host cells negative regulation of cytolysis in other organism negative regulation of cytolysis in other organism involved in symbiotic interaction negative regulation of cytoplasmic mRNA processing body assembly negative regulation of cytoplasmic translation negative regulation of cytoplasmic translational elongation negative regulation of cytoplasmic translational elongation through polyproline stretches negative regulation of cytoplasmic translational initiation negative regulation of cytoplasmic transport negative regulation of cytoskeleton organization negative regulation of cytotoxic T cell degranulation negative regulation of cytotoxic T cell differentiation negative regulation of D-amino-acid oxidase activity negative regulation of dauer entry negative regulation of dauer larval development negative regulation of dCDP biosynthetic process negative regulation of death-inducing signaling complex assembly negative regulation of defecation negative regulation of defecation rhythm negative regulation of defense response negative regulation of defense response to bacterium negative regulation of defense response to bacterium, incompatible interaction negative regulation of defense response to insect negative regulation of defense response to oomycetes negative regulation of defense response to virus negative regulation of dehydroaustinol biosynthetic process negative regulation of dehydroepiandrosterone secretion negative regulation of delayed rectifier potassium channel activity negative regulation of demethylkotanin biosynthetic process negative regulation of dendrite development negative regulation of dendrite extension negative regulation of dendrite morphogenesis negative regulation of dendritic cell antigen processing and presentation negative regulation of dendritic cell apoptotic process negative regulation of dendritic cell chemotaxis negative regulation of dendritic cell cytokine production negative regulation of dendritic cell dendrite assembly negative regulation of dendritic cell differentiation negative regulation of dendritic spine development negative regulation of dendritic spine maintenance negative regulation of dendritic spine morphogenesis negative regulation of dense core granule biogenesis negative regulation of dense core granule exocytosis negative regulation of dense core granule transport negative regulation of deoxyribonuclease activity negative regulation of dephosphorylation negative regulation of dermatome development negative regulation of detection of glucose negative regulation of detection of mechanical stimulus involved in sensory perception of touch negative regulation of determination of dorsal identity negative regulation of development of symbiont in host negative regulation of development of symbiont involved in interaction with host negative regulation of developmental growth negative regulation of developmental pigmentation negative regulation of developmental process negative regulation of developmental vegetative growth negative regulation of diacylglycerol biosynthetic process negative regulation of diacylglycerol kinase activity negative regulation of digestive system process negative regulation of diorcinol biosynthetic process negative regulation of dipeptide transmembrane transport negative regulation of dipeptide transport negative regulation of distal tip cell migration negative regulation of division septum assembly negative regulation of DNA amplification negative regulation of DNA binding negative regulation of DNA biosynthetic process negative regulation of DNA catabolic process negative regulation of DNA damage checkpoint negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator negative regulation of DNA demethylation negative regulation of DNA duplex unwinding negative regulation of DNA endoreduplication negative regulation of DNA helicase activity negative regulation of DNA ligase activity negative regulation of DNA ligation negative regulation of DNA metabolic process negative regulation of DNA methylation negative regulation of DNA N-glycosylase activity negative regulation of DNA nucleotidylexotransferase activity negative regulation of DNA primase activity negative regulation of DNA recombinase disassembly negative regulation of DNA recombinase mediator complex assembly negative regulation of DNA recombination negative regulation of DNA repair negative regulation of DNA replication negative regulation of DNA replication origin binding negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity negative regulation of DNA-dependent DNA replication negative regulation of DNA-dependent DNA replication initiation negative regulation of DNA-directed DNA polymerase activity negative regulation of DNA-templated transcription, elongation negative regulation of DNA-templated transcription, initiation negative regulation of DNA-templated transcription, termination negative regulation of dopamine biosynthetic process negative regulation of dopamine metabolic process negative regulation of dopamine receptor signaling pathway negative regulation of dopamine secretion negative regulation of dopamine uptake involved in synaptic transmission negative regulation of dopaminergic neuron differentiation negative regulation of dorsal/ventral axon guidance negative regulation of dosage compensation by inactivation of X chromosome negative regulation of double-strand break repair negative regulation of double-strand break repair via break-induced replication negative regulation of double-strand break repair via homologous recombination negative regulation of double-strand break repair via nonhomologous end joining negative regulation of double-strand break repair via single-strand annealing negative regulation of double-stranded telomeric DNA binding negative regulation of ductus arteriosus closure negative regulation of dUTP diphosphatase activity negative regulation of early endosome to late endosome transport negative regulation of early stripe melanocyte differentiation negative regulation of eating behavior negative regulation of ecdysone receptor-mediated signaling pathway negative regulation of ecdysteroid biosynthetic process negative regulation of ecdysteroid metabolic process negative regulation of ecdysteroid secretion negative regulation of eclosion negative regulation of ectoderm development negative regulation of ectodermal cell fate specification negative regulation of elastin biosynthetic process negative regulation of elastin catabolic process negative regulation of electron transfer activity negative regulation of embryo sac central cell differentiation negative regulation of embryo sac egg cell differentiation negative regulation of embryonic camera-type eye development negative regulation of embryonic development negative regulation of embryonic pattern specification negative regulation of embryonic skeletal joint development negative regulation of emericellamide A biosynthetic process negative regulation of emericellamide biosynthetic process negative regulation of emericellin biosynthetic process negative regulation of emodin biosynthetic process negative regulation of enamel mineralization negative regulation of encysted zoospore germination on or near host negative regulation of endo-1,4-beta-xylanase activity negative regulation of endocardial cushion cell differentiation negative regulation of endocardial cushion to mesenchymal transition negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation negative regulation of endocrocin biosynthetic process negative regulation of endocytic recycling negative regulation of endocytosis negative regulation of endodeoxyribonuclease activity negative regulation of endodermal cell differentiation negative regulation of endodermal cell fate specification negative regulation of endopeptidase activity negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum tubular network organization negative regulation of endoplasmic reticulum unfolded protein response negative regulation of endoribonuclease activity negative regulation of endosomal vesicle fusion negative regulation of endosome organization negative regulation of endosome to plasma membrane protein transport negative regulation of endosperm development negative regulation of endothelial cell activation negative regulation of endothelial cell apoptotic process negative regulation of endothelial cell chemotaxis negative regulation of endothelial cell chemotaxis to fibroblast growth factor negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor negative regulation of endothelial cell development negative regulation of endothelial cell differentiation negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of endothelial cell-matrix adhesion via fibronectin negative regulation of endothelial microparticle formation negative regulation of endothelin secretion negative regulation of engulfment of apoptotic cell negative regulation of ent-pimara-8(14),15-diene biosynthetic process negative regulation of entry of bacterium into host cell negative regulation of eosinophil activation negative regulation of eosinophil chemotaxis negative regulation of eosinophil degranulation negative regulation of eosinophil differentiation negative regulation of eosinophil extravasation negative regulation of eosinophil migration negative regulation of ephrin receptor signaling pathway negative regulation of epiboly involved in gastrulation with mouth forming second negative regulation of epidermal cell differentiation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway involved in heart process negative regulation of epidermal growth factor-activated receptor activity negative regulation of epidermis development negative regulation of epinephrine secretion negative regulation of epinephrine uptake negative regulation of epithelial cell apoptotic process negative regulation of epithelial cell differentiation negative regulation of epithelial cell differentiation involved in kidney development negative regulation of epithelial cell migration negative regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of epithelial cell-cell adhesion involved in epithelium migration negative regulation of epithelial to mesenchymal transition negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation negative regulation of epithelial tube formation negative regulation of epithelium regeneration negative regulation of ER-associated ubiquitin-dependent protein catabolic process negative regulation of ERAD pathway negative regulation of ERBB signaling pathway negative regulation of ERBB3 signaling pathway negative regulation of ERBB4 signaling pathway negative regulation of ergosterol biosynthetic process negative regulation of ergot alkaloid biosynthetic process negative regulation of ERK1 and ERK2 cascade negative regulation of ERK5 cascade negative regulation of error-prone translesion synthesis negative regulation of erythrocyte aggregation negative regulation of erythrocyte apoptotic process negative regulation of erythrocyte clearance negative regulation of erythrocyte differentiation negative regulation of erythrocyte enucleation negative regulation of erythrophore differentiation negative regulation of establishment of bipolar cell polarity negative regulation of establishment of blood-brain barrier negative regulation of establishment of cell polarity regulating cell shape negative regulation of establishment of competence for transformation negative regulation of establishment of endothelial barrier negative regulation of establishment of protein localization negative regulation of establishment of protein localization to mitochondrion negative regulation of establishment of protein localization to telomere negative regulation of establishment of protein-containing complex localization to telomere negative regulation of establishment of RNA localization to telomere negative regulation of establishment of Sertoli cell barrier negative regulation of establishment of T cell polarity negative regulation of establishment of turgor in appressorium negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape negative regulation of establishment or maintenance of cell polarity regulating cell shape negative regulation of establishment or maintenance of neuroblast polarity negative regulation of estradiol secretion negative regulation of estrogen biosynthetic process negative regulation of estrogen receptor binding negative regulation of estrogen secretion negative regulation of estrone secretion negative regulation of ethylene biosynthetic process negative regulation of ethylene-activated signaling pathway negative regulation of euchromatin binding negative regulation of eukaryotic translation initiation factor 4F complex assembly negative regulation of excitatory synapse assembly negative regulation of excitatory synapse pruning negative regulation of execution phase of apoptosis negative regulation of exit from meiosis negative regulation of exit from mitosis negative regulation of exo-alpha-sialidase activity negative regulation of exocyst assembly negative regulation of exocytosis negative regulation of exodeoxyribonuclease activity negative regulation of exonuclease activity negative regulation of exoribonuclease activity negative regulation of exosomal secretion negative regulation of extracellular exosome assembly negative regulation of extracellular matrix assembly negative regulation of extracellular matrix constituent secretion negative regulation of extracellular matrix disassembly negative regulation of extracellular matrix organization negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging negative regulation of extraocular skeletal muscle development negative regulation of extrathymic T cell differentiation negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of eye photoreceptor cell development negative regulation of eye pigmentation negative regulation of F-9775A biosynthetic process negative regulation of F-9775B biosynthetic process negative regulation of FACT complex assembly negative regulation of Fas signaling pathway negative regulation of FasL biosynthetic process negative regulation of fast-twitch skeletal muscle fiber contraction negative regulation of fat cell apoptotic process negative regulation of fat cell differentiation negative regulation of fat cell proliferation negative regulation of fatty acid beta-oxidation negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase negative regulation of fatty acid biosynthetic process negative regulation of fatty acid metabolic process negative regulation of fatty acid oxidation negative regulation of fatty acid transport negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of fear response negative regulation of feeding behavior negative regulation of female gonad development negative regulation of female pigmentation negative regulation of fermentation negative regulation of ferrichrome biosynthetic process negative regulation of ferricrocin biosynthetic process negative regulation of ferroptosis negative regulation of ferrous iron binding negative regulation of fertilization negative regulation of ferulate catabolic process negative regulation of fever generation negative regulation of fibrinolysis negative regulation of fibroblast apoptotic process negative regulation of fibroblast chemotaxis negative regulation of fibroblast growth factor production negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation negative regulation of fibroblast migration negative regulation of fibroblast proliferation negative regulation of fibronectin-dependent thymocyte migration negative regulation of filamentous growth negative regulation of filamentous growth of a population of unicellular organisms negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus negative regulation of filamentous growth of a population of unicellular organisms in response to heat negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH negative regulation of filamentous growth of a population of unicellular organisms in response to pH negative regulation of filamentous growth of a population of unicellular organisms in response to starvation negative regulation of filopodium assembly negative regulation of flagellated sperm motility negative regulation of flavonoid biosynthetic process negative regulation of flavonol biosynthetic process negative regulation of flocculation negative regulation of floral organ abscission negative regulation of flower development negative regulation of focal adhesion assembly negative regulation of focal adhesion disassembly negative regulation of follicle-stimulating hormone secretion negative regulation of foraging behavior negative regulation of forebrain neuron differentiation negative regulation of formation by symbiont of haustorium for nutrient acquisition from host negative regulation of formation of radial glial scaffolds negative regulation of formation of translation initiation ternary complex negative regulation of formation of translation preinitiation complex negative regulation of formin-nucleated actin cable assembly negative regulation of forward locomotion negative regulation of fractalkine biosynthetic process negative regulation of fractalkine production negative regulation of free ubiquitin chain polymerization negative regulation of FtsZ-dependent cytokinesis negative regulation of fumagillin biosynthetic process negative regulation of fumigaclavine C biosynthetic process negative regulation of fumitremorgin B biosynthetic process negative regulation of fumonisin biosynthetic process negative regulation of fusion cell fate specification negative regulation of fusion of sperm to egg plasma membrane negative regulation of fusion of virus membrane with host plasma membrane negative regulation of G protein-coupled receptor internalization negative regulation of G protein-coupled receptor signaling pathway negative regulation of G-quadruplex DNA binding negative regulation of G-quadruplex DNA unwinding negative regulation of G0 to G1 transition negative regulation of G1 to G0 transition negative regulation of G1/S transition of mitotic cell cycle negative regulation of G2/M transition of mitotic cell cycle negative regulation of G2/MI transition of meiotic cell cycle negative regulation of GABA-A receptor activity negative regulation of galactoglucomannan catabolic process negative regulation of galactomannan catabolic process negative regulation of galactotriose transport negative regulation of gamma-aminobutyric acid catabolic process negative regulation of gamma-aminobutyric acid secretion negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse negative regulation of gamma-delta T cell activation negative regulation of gamma-delta T cell activation involved in immune response negative regulation of gamma-delta T cell differentiation negative regulation of gamma-delta T cell proliferation negative regulation of gap junction assembly negative regulation of gastric acid secretion negative regulation of gastric emptying negative regulation of gastric mucosal blood circulation negative regulation of gastrin-induced gastric acid secretion negative regulation of gastro-intestinal system smooth muscle contraction negative regulation of gastrulation negative regulation of gene expression negative regulation of gene silencing negative regulation of gene silencing by miRNA negative regulation of gene silencing by RNA negative regulation of gerfelin biosynthetic process negative regulation of germ tube formation on or near host negative regulation of germinal center formation negative regulation of gibberellic acid mediated signaling pathway negative regulation of gibberellin biosynthetic process negative regulation of glial cell apoptotic process negative regulation of glial cell differentiation negative regulation of glial cell migration negative regulation of glial cell proliferation negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation negative regulation of glial cell-derived neurotrophic factor secretion negative regulation of gliogenesis negative regulation of gliotoxin biosynthetic process negative regulation of glomerular filtration negative regulation of glomerular mesangial cell proliferation negative regulation of glomerular visceral epithelial cell apoptotic process negative regulation of glomerulus development negative regulation of glucagon secretion negative regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid catabolic process negative regulation of glucocorticoid mediated signaling pathway negative regulation of glucocorticoid metabolic process negative regulation of glucocorticoid receptor signaling pathway negative regulation of glucocorticoid secretion negative regulation of glucokinase activity negative regulation of glucomannan catabolic process negative regulation of gluconate transmembrane transport negative regulation of gluconeogenesis negative regulation of glucose catabolic process to lactate via pyruvate negative regulation of glucose import negative regulation of glucose mediated signaling pathway negative regulation of glucose transmembrane transport negative regulation of glucosylceramidase activity negative regulation of glucosylceramide biosynthetic process negative regulation of glucuronoarabinoxylan catabolic process negative regulation of glucuronosyltransferase activity negative regulation of glucuronoxylan catabolic process negative regulation of glutamate metabolic process negative regulation of glutamate receptor signaling pathway negative regulation of glutamate secretion negative regulation of glutamate secretion, neurotransmission negative regulation of glutamate uptake involved in transmission of nerve impulse negative regulation of glutamate-ammonia ligase activity negative regulation of glutamate-cysteine ligase activity negative regulation of glutamatergic neuron differentiation negative regulation of glutamine transport negative regulation of glutathione biosynthetic process negative regulation of glutathione peroxidase activity negative regulation of glycerol transport negative regulation of glycine import across plasma membrane negative regulation of glycine secretion, neurotransmission negative regulation of glycogen (starch) synthase activity negative regulation of glycogen biosynthetic process negative regulation of glycogen catabolic process negative regulation of glycogen metabolic process negative regulation of glycogen synthase activity, transferring glucose-1-phosphate negative regulation of glycolytic fermentation to ethanol negative regulation of glycolytic process negative regulation of glycolytic process through fructose-6-phosphate negative regulation of glycoprotein biosynthetic process negative regulation of glycoprotein metabolic process negative regulation of glyoxylate cycle negative regulation of Golgi lumen acidification negative regulation of Golgi to plasma membrane CFTR protein transport negative regulation of Golgi to plasma membrane protein transport negative regulation of Golgi vesicle fusion to target membrane negative regulation of gonadotropin secretion negative regulation of granulocyte chemotaxis negative regulation of granulocyte colony-stimulating factor production negative regulation of granulocyte differentiation negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process negative regulation of granulocyte macrophage colony-stimulating factor production negative regulation of granuloma formation negative regulation of granulosa cell apoptotic process negative regulation of granulosa cell proliferation negative regulation of granzyme A production negative regulation of granzyme B production negative regulation of growth negative regulation of growth hormone activity negative regulation of growth hormone receptor signaling pathway negative regulation of growth hormone secretion negative regulation of growth of unicellular organism as a thread of attached cells negative regulation of growth plate cartilage chondrocyte proliferation negative regulation of GTP binding negative regulation of GTP cyclohydrolase I activity negative regulation of GTPase activity negative regulation of guanyl-nucleotide exchange factor activity negative regulation of gut granule assembly negative regulation of hair cycle negative regulation of hair follicle cell proliferation negative regulation of hair follicle development negative regulation of hair follicle maturation negative regulation of hair follicle placode formation negative regulation of haustorium mother cell formation on or near host negative regulation of heart contraction negative regulation of heart growth negative regulation of heart induction negative regulation of heart looping negative regulation of heat dissipation negative regulation of heat generation negative regulation of helicase activity negative regulation of helvolic acid biosynthetic process negative regulation of hematopoietic progenitor cell differentiation negative regulation of hematopoietic stem cell differentiation negative regulation of hematopoietic stem cell migration negative regulation of hematopoietic stem cell proliferation negative regulation of heme biosynthetic process negative regulation of hemicellulose catabolic process negative regulation of hemocyte differentiation negative regulation of hemocyte proliferation negative regulation of hemoglobin biosynthetic process negative regulation of hemopoiesis negative regulation of hemostasis negative regulation of heparan sulfate binding negative regulation of heparan sulfate proteoglycan binding negative regulation of hepatic stellate cell activation negative regulation of hepatic stellate cell contraction negative regulation of hepatic stellate cell migration negative regulation of hepatic stellate cell proliferation negative regulation of hepatocyte apoptotic process negative regulation of hepatocyte differentiation negative regulation of hepatocyte growth factor biosynthetic process negative regulation of hepatocyte growth factor production negative regulation of hepatocyte growth factor receptor signaling pathway negative regulation of hepatocyte proliferation negative regulation of heptadecane biosynthetic process negative regulation of heptadecane metabolic process negative regulation of heptasaccharide transport negative regulation of heterochromatin assembly negative regulation of heterotypic cell-cell adhesion negative regulation of hexadecanal biosynthetic process negative regulation of hexadecanal metabolic process negative regulation of hexasaccharide transport negative regulation of hexokinase activity negative regulation of high voltage-gated calcium channel activity negative regulation of high-density lipoprotein particle clearance negative regulation of hindgut contraction negative regulation of hippo signaling negative regulation of histamine secretion by mast cell negative regulation of histamine uptake negative regulation of histidine biosynthetic process negative regulation of histone acetylation negative regulation of histone deacetylase activity negative regulation of histone deacetylation negative regulation of histone deacetylation at centromere negative regulation of histone demethylase activity (H3-K4 specific) negative regulation of histone deubiquitination negative regulation of histone exchange negative regulation of histone H2A K63-linked ubiquitination negative regulation of histone H2A-H2B dimer displacement negative regulation of histone H2B conserved C-terminal lysine ubiquitination negative regulation of histone H2B ubiquitination negative regulation of histone H3-K4 methylation negative regulation of histone H3-K4 trimethylation negative regulation of histone H3-K9 acetylation negative regulation of histone H3-K9 dimethylation negative regulation of histone H3-K9 methylation negative regulation of histone H3-K9 trimethylation negative regulation of histone H3-K14 acetylation negative regulation of histone H3-K18 acetylation negative regulation of histone H3-K27 acetylation negative regulation of histone H3-K27 methylation negative regulation of histone H3-K27 trimethylation negative regulation of histone H3-K36 methylation negative regulation of histone H3-K36 trimethylation negative regulation of histone H3-K79 dimethylation negative regulation of histone H3-K79 methylation negative regulation of histone H3-S10 phosphorylation negative regulation of histone H4 acetylation negative regulation of histone H4-K16 acetylation negative regulation of histone H4-K20 methylation negative regulation of histone methylation negative regulation of histone modification negative regulation of histone phosphorylation negative regulation of histone ubiquitination negative regulation of holin activity negative regulation of homocysteine metabolic process negative regulation of homophilic cell adhesion negative regulation of homoserine biosynthetic process negative regulation of homotypic cell-cell adhesion negative regulation of horizontal cell localization negative regulation of hormone biosynthetic process negative regulation of hormone metabolic process negative regulation of hormone secretion negative regulation of host-seeking behavior negative regulation of Hulle cell development negative regulation of humoral immune response negative regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of hyaluranon cable assembly negative regulation of hyaluronan biosynthetic process negative regulation of hydrogen peroxide biosynthetic process negative regulation of hydrogen peroxide catabolic process negative regulation of hydrogen peroxide metabolic process negative regulation of hydrogen peroxide-induced cell death negative regulation of hydrogen peroxide-induced neuron death negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of hydrogen sulfide biosynthetic process negative regulation of hydrolase activity negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity negative regulation of hypersensitivity negative regulation of hyphopodium formation on or near host negative regulation of hypoxanthine transport negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of hypoxia-inducible factor-1alpha signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB phosphorylation negative regulation of icosanoid secretion negative regulation of imaginal disc growth negative regulation of immature T cell proliferation negative regulation of immature T cell proliferation in thymus negative regulation of immune effector process negative regulation of immune response negative regulation of immune response to tumor cell negative regulation of immune system process negative regulation of immunoglobulin biosynthetic process negative regulation of immunoglobulin mediated immune response negative regulation of immunoglobulin production negative regulation of immunoglobulin secretion negative regulation of immunological synapse formation negative regulation of inclusion body assembly negative regulation of indoleacetic acid biosynthetic process via tryptophan negative regulation of induction of conjugation with cellular fusion negative regulation of infection cushion formation on or near host negative regulation of inflammatory response negative regulation of inflammatory response to antigenic stimulus negative regulation of inhibin secretion negative regulation of inhibitory G protein-coupled receptor phosphorylation negative regulation of inhibitory synapse assembly negative regulation of initiation of acetate catabolic process by acetate negative regulation of initiation of premeiotic DNA replication negative regulation of innate immune response negative regulation of innate immunity memory response negative regulation of inner ear auditory receptor cell differentiation negative regulation of inner ear receptor cell differentiation negative regulation of inorganic anion transmembrane transport negative regulation of inosine transport negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity negative regulation of inositol biosynthetic process negative regulation of inositol phosphate biosynthetic process negative regulation of inositol trisphosphate biosynthetic process negative regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan negative regulation of insulin secretion negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of integrin activation negative regulation of integrin biosynthetic process negative regulation of integrin-mediated signaling pathway negative regulation of interferon-alpha biosynthetic process negative regulation of interferon-alpha production negative regulation of interferon-alpha secretion negative regulation of interferon-beta biosynthetic process negative regulation of interferon-beta production negative regulation of interferon-beta secretion negative regulation of interferon-gamma biosynthetic process negative regulation of interferon-gamma production negative regulation of interferon-gamma secretion negative regulation of interferon-gamma-mediated signaling pathway negative regulation of interleukin-1 alpha biosynthetic process negative regulation of interleukin-1 alpha production negative regulation of interleukin-1 alpha secretion negative regulation of interleukin-1 beta biosynthetic process negative regulation of interleukin-1 beta production negative regulation of interleukin-1 beta secretion negative regulation of interleukin-1 biosynthetic process negative regulation of interleukin-1 production negative regulation of interleukin-1 secretion negative regulation of interleukin-1-mediated signaling pathway negative regulation of interleukin-2 biosynthetic process negative regulation of interleukin-2 production negative regulation of interleukin-2 secretion negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-3 biosynthetic process negative regulation of interleukin-3 production negative regulation of interleukin-4 biosynthetic process negative regulation of interleukin-4 production negative regulation of interleukin-4-mediated signaling pathway negative regulation of interleukin-5 biosynthetic process negative regulation of interleukin-5 production negative regulation of interleukin-5 secretion negative regulation of interleukin-6 biosynthetic process negative regulation of interleukin-6 production negative regulation of interleukin-6 secretion negative regulation of interleukin-6-mediated signaling pathway negative regulation of interleukin-7 biosynthetic process negative regulation of interleukin-7 production negative regulation of interleukin-8 biosynthetic process negative regulation of interleukin-8 production negative regulation of interleukin-8 secretion negative regulation of interleukin-9 biosynthetic process negative regulation of interleukin-9 production negative regulation of interleukin-10 biosynthetic process negative regulation of interleukin-10 production negative regulation of interleukin-10 secretion negative regulation of interleukin-11 biosynthetic process negative regulation of interleukin-11 production negative regulation of interleukin-12 biosynthetic process negative regulation of interleukin-12 production negative regulation of interleukin-12 secretion negative regulation of interleukin-13 biosynthetic process negative regulation of interleukin-13 production negative regulation of interleukin-13 secretion negative regulation of interleukin-14 biosynthetic process negative regulation of interleukin-14 production negative regulation of interleukin-15 biosynthetic process negative regulation of interleukin-15 production negative regulation of interleukin-16 biosynthetic process negative regulation of interleukin-16 production negative regulation of interleukin-17 biosynthetic process negative regulation of interleukin-17 production negative regulation of interleukin-17 secretion negative regulation of interleukin-17-mediated signaling pathway negative regulation of interleukin-18 biosynthetic process negative regulation of interleukin-18 production negative regulation of interleukin-18-mediated signaling pathway negative regulation of interleukin-19 biosynthetic process negative regulation of interleukin-19 production negative regulation of interleukin-20 biosynthetic process negative regulation of interleukin-20 production negative regulation of interleukin-21 biosynthetic process negative regulation of interleukin-21 production negative regulation of interleukin-22 biosynthetic process negative regulation of interleukin-22 production negative regulation of interleukin-23 biosynthetic process negative regulation of interleukin-23 production negative regulation of interleukin-24 biosynthetic process negative regulation of interleukin-24 production negative regulation of interleukin-25 biosynthetic process negative regulation of interleukin-25 production negative regulation of interleukin-26 biosynthetic process negative regulation of interleukin-26 production negative regulation of interleukin-27 biosynthetic process negative regulation of interleukin-27 production negative regulation of interleukin-27-mediated signaling pathway negative regulation of interleukin-35 biosynthetic process negative regulation of interleukin-35 production negative regulation of interleukin-35-mediated signaling pathway negative regulation of intermediate filament depolymerization negative regulation of intermediate filament polymerization negative regulation of intermediate mesodermal cell fate determination negative regulation of intermediate mesodermal cell fate specification negative regulation of interphase mitotic telomere clustering negative regulation of intestinal absorption negative regulation of intestinal cholesterol absorption negative regulation of intestinal epithelial cell development negative regulation of intestinal lipid absorption negative regulation of intestinal phytosterol absorption negative regulation of intracellular calcium activated chloride channel activity negative regulation of intracellular cholesterol transport negative regulation of intracellular estrogen receptor signaling pathway negative regulation of intracellular lipid transport negative regulation of intracellular mRNA localization negative regulation of intracellular protein transport negative regulation of intracellular signal transduction negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of intracellular sterol transport negative regulation of intracellular transport negative regulation of intracellular transport of viral material negative regulation of intraciliary anterograde transport negative regulation of intraciliary retrograde transport negative regulation of intralumenal vesicle formation negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator negative regulation of invasive growth in response to glucose limitation negative regulation of inward rectifier potassium channel activity negative regulation of iodide transmembrane transport negative regulation of iodide transport negative regulation of ion transmembrane transport negative regulation of ion transmembrane transporter activity negative regulation of ion transport negative regulation of IP-10 production negative regulation of IRE1-mediated unfolded protein response negative regulation of iridophore differentiation negative regulation of iron ion import across plasma membrane negative regulation of iron ion transmembrane transport negative regulation of iron ion transmembrane transporter activity negative regulation of iron ion transport negative regulation of iron-sulfur cluster assembly negative regulation of iron-sulfur-molybdenum cofactor assembly negative regulation of isoleucine-tRNA ligase activity negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway negative regulation of isoprene biosynthetic process negative regulation of isoprene metabolic process negative regulation of isoprenoid metabolic process negative regulation of isotype switching negative regulation of isotype switching to IgA isotypes negative regulation of isotype switching to IgD isotypes negative regulation of isotype switching to IgE isotypes negative regulation of isotype switching to IgG isotypes negative regulation of JNK cascade negative regulation of JUN kinase activity negative regulation of juvenile hormone biosynthetic process negative regulation of juvenile hormone catabolic process negative regulation of juvenile hormone metabolic process negative regulation of juvenile hormone secretion negative regulation of keratinocyte apoptotic process negative regulation of keratinocyte differentiation negative regulation of keratinocyte migration negative regulation of keratinocyte proliferation negative regulation of kidney development negative regulation of kidney smooth muscle cell differentiation negative regulation of killing of cells of other organism negative regulation of kinase activity negative regulation of kinetochore assembly negative regulation of kinin cascade negative regulation of Kit signaling pathway negative regulation of kojic acid biosynthetic process negative regulation of L-arginine import across plasma membrane negative regulation of L-ascorbic acid biosynthetic process negative regulation of L-dopa biosynthetic process negative regulation of L-dopa decarboxylase activity negative regulation of L-glutamate import across plasma membrane negative regulation of L-glutamine biosynthetic process negative regulation of L-glutamine import across plasma membrane negative regulation of L-lysine import across plasma membrane negative regulation of L-methionine import across plasma membrane negative regulation of L-proline import across plasma membrane negative regulation of L-threonine import across plasma membrane negative regulation of L-tyrosine import across plasma membrane negative regulation of lactation negative regulation of lactose biosynthetic process negative regulation of lamellipodium assembly negative regulation of lamellipodium morphogenesis negative regulation of lamellipodium organization negative regulation of lamellocyte differentiation negative regulation of laminarabiose transport negative regulation of laminaritriose transport negative regulation of large conductance calcium-activated potassium channel activity negative regulation of larval salivary gland boundary specification negative regulation of late endosome to lysosome transport negative regulation of late stripe melanocyte differentiation negative regulation of lateral mesodermal cell fate determination negative regulation of lateral mesodermal cell fate specification negative regulation of lateral motor column neuron migration negative regulation of lateral pseudopodium assembly negative regulation of lateral root development negative regulation of leaf development negative regulation of leaf senescence negative regulation of lens epithelial cell proliferation negative regulation of lens fiber cell differentiation negative regulation of leucine biosynthetic process negative regulation of leucine import negative regulation of leucine import across plasma membrane negative regulation of leucine-tRNA ligase activity negative regulation of leucophore differentiation negative regulation of leukocyte activation negative regulation of leukocyte adhesion to arterial endothelial cell negative regulation of leukocyte adhesion to vascular endothelial cell negative regulation of leukocyte apoptotic process negative regulation of leukocyte cell-cell adhesion negative regulation of leukocyte chemotaxis negative regulation of leukocyte degranulation negative regulation of leukocyte differentiation negative regulation of leukocyte mediated cytotoxicity negative regulation of leukocyte mediated immunity negative regulation of leukocyte migration negative regulation of leukocyte proliferation negative regulation of leukocyte tethering or rolling negative regulation of leukotriene production involved in inflammatory response negative regulation of ligase activity negative regulation of light-activated channel activity negative regulation of lipase activity negative regulation of lipid binding negative regulation of lipid biosynthetic process negative regulation of lipid catabolic process negative regulation of lipid kinase activity negative regulation of lipid metabolic process negative regulation of lipid storage negative regulation of lipid transport negative regulation of lipid transport across blood-brain barrier negative regulation of lipophagy negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of lipoprotein lipase activity negative regulation of lipoprotein lipid oxidation negative regulation of lipoprotein metabolic process negative regulation of lipoprotein oxidation negative regulation of lipoprotein particle clearance negative regulation of locomotion negative regulation of locomotion involved in locomotory behavior negative regulation of locomotor rhythm negative regulation of long-chain fatty acid import across plasma membrane negative regulation of long-day photoperiodism, flowering negative regulation of long-term synaptic depression negative regulation of long-term synaptic potentiation negative regulation of low-density lipoprotein particle clearance negative regulation of low-density lipoprotein particle receptor binding negative regulation of low-density lipoprotein particle receptor biosynthetic process negative regulation of low-density lipoprotein particle receptor catabolic process negative regulation of low-density lipoprotein receptor activity negative regulation of lung alveolus development negative regulation of lung ciliated cell differentiation negative regulation of lung goblet cell differentiation negative regulation of luteinizing hormone secretion negative regulation of lyase activity negative regulation of lymphangiogenesis negative regulation of lymphocyte activation negative regulation of lymphocyte anergy negative regulation of lymphocyte apoptotic process negative regulation of lymphocyte chemotaxis negative regulation of lymphocyte differentiation negative regulation of lymphocyte mediated immunity negative regulation of lymphocyte migration negative regulation of lymphocyte proliferation negative regulation of lymphoid progenitor cell differentiation negative regulation of lymphotoxin A biosynthetic process negative regulation of lymphotoxin A production negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine negative regulation of lysine biosynthetic process via aminoadipic acid negative regulation of lysosomal protein catabolic process negative regulation of lysosome organization negative regulation of lysozyme activity negative regulation of macroautophagy negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of macrophage activation negative regulation of macrophage antigen processing and presentation negative regulation of macrophage apoptotic process negative regulation of macrophage chemotaxis negative regulation of macrophage colony-stimulating factor production negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of macrophage cytokine production negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage differentiation negative regulation of macrophage fusion negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of macrophage inflammatory protein-1 gamma production negative regulation of macrophage migration negative regulation of macrophage migration inhibitory factor signaling pathway negative regulation of macrophage proliferation negative regulation of macropinocytosis negative regulation of maintenance of meiotic sister chromatid cohesion negative regulation of maintenance of meiotic sister chromatid cohesion, arms negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric negative regulation of maintenance of mitotic actomyosin contractile ring localization negative regulation of maintenance of mitotic sister chromatid cohesion negative regulation of maintenance of mitotic sister chromatid cohesion, arms negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric negative regulation of maintenance of permeability of blood-brain barrier negative regulation of maintenance of sister chromatid cohesion negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity negative regulation of male germ cell proliferation negative regulation of male germ-line stem cell asymmetric division negative regulation of male gonad development negative regulation of male mating behavior negative regulation of male pigmentation negative regulation of maltoheptaose metabolic process negative regulation of maltoheptaose transport negative regulation of maltohexaose transport negative regulation of maltopentaose transport negative regulation of maltose transport negative regulation of maltotetraose transport negative regulation of maltotriulose transport negative regulation of mammary gland epithelial cell proliferation negative regulation of mammary gland involution negative regulation of mammary stem cell proliferation negative regulation of mannan catabolic process negative regulation of mannotriose transport negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of MAPK cascade involved in axon regeneration negative regulation of MAPK cascade involved in cell wall organization or biogenesis negative regulation of mast cell activation negative regulation of mast cell activation involved in immune response negative regulation of mast cell apoptotic process negative regulation of mast cell chemotaxis negative regulation of mast cell cytokine production negative regulation of mast cell degranulation negative regulation of mast cell differentiation negative regulation of mast cell proliferation negative regulation of maternal process involved in parturition negative regulation of mating type switching negative regulation of matrix metallopeptidase secretion negative regulation of mature B cell apoptotic process negative regulation of MDA-5 signaling pathway negative regulation of mechanoreceptor differentiation negative regulation of mechanosensory behavior negative regulation of mediator complex assembly negative regulation of megakaryocyte differentiation negative regulation of meiosis I negative regulation of meiotic cell cycle negative regulation of meiotic cell cycle phase transition negative regulation of meiotic cell cycle process involved in oocyte maturation negative regulation of meiotic chromosome separation negative regulation of meiotic DNA double-strand break formation negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination negative regulation of meiotic joint molecule formation negative regulation of meiotic nuclear division negative regulation of meiotic spindle elongation negative regulation of melanin biosynthetic process negative regulation of melanization defense response negative regulation of melanocyte differentiation negative regulation of melanosome organization negative regulation of melanosome transport negative regulation of membrane depolarization negative regulation of membrane depolarization during AV node cell action potential negative regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of membrane hyperpolarization negative regulation of membrane invagination negative regulation of membrane protein ectodomain proteolysis negative regulation of membrane repolarization during atrial cardiac muscle cell action potential negative regulation of membrane repolarization during cardiac muscle cell action potential negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential negative regulation of membrane tubulation negative regulation of memory T cell differentiation negative regulation of mesenchymal cell apoptotic process negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis negative regulation of mesenchymal cell proliferation negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of mesenchymal cell proliferation involved in ureter development negative regulation of mesenchymal stem cell differentiation negative regulation of mesenchymal stem cell migration negative regulation of mesenchymal stem cell proliferation negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of mesoderm development negative regulation of mesoderm formation negative regulation of mesodermal cell differentiation negative regulation of mesodermal cell fate determination negative regulation of mesodermal cell fate specification negative regulation of mesonephric glomerular mesangial cell proliferation negative regulation of mesonephric glomerulus development negative regulation of mesonephric nephron tubule epithelial cell differentiation negative regulation of mesonephros development negative regulation of metabolic process negative regulation of metalloendopeptidase activity negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metallopeptidase activity negative regulation of metanephric comma-shaped body morphogenesis negative regulation of metanephric DCT cell differentiation negative regulation of metanephric glomerular mesangial cell proliferation negative regulation of metanephric glomerulus development negative regulation of metanephric mesenchymal cell migration negative regulation of metanephric nephron tubule epithelial cell differentiation negative regulation of metanephric S-shaped body morphogenesis negative regulation of metanephric ureteric bud development negative regulation of metanephros development negative regulation of metaphase/anaphase transition of cell cycle negative regulation of metaphase/anaphase transition of meiosis I negative regulation of metaphase/anaphase transition of meiosis II negative regulation of metaphase/anaphase transition of meiotic cell cycle negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid negative regulation of methane biosynthetic process from carbon monoxide negative regulation of methane biosynthetic process from dimethyl sulfide negative regulation of methane biosynthetic process from dimethylamine negative regulation of methane biosynthetic process from formic acid negative regulation of methane biosynthetic process from methanethiol negative regulation of methane biosynthetic process from methylamine negative regulation of methane biosynthetic process from trimethylamine negative regulation of methanofuran biosynthetic process negative regulation of methanofuran metabolic process negative regulation of methanophenazine biosynthetic process negative regulation of methanophenazine metabolic process negative regulation of methionine-tRNA ligase activity negative regulation of methyl-branched fatty acid biosynthetic process negative regulation of methylation-dependent chromatin silencing negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity negative regulation of metula development negative regulation of MHC class I biosynthetic process negative regulation of MHC class II biosynthetic process negative regulation of microfilament motor activity negative regulation of microglia differentiation negative regulation of microglial cell activation negative regulation of microglial cell mediated cytotoxicity negative regulation of microglial cell migration negative regulation of microtubule binding negative regulation of microtubule depolymerization negative regulation of microtubule motor activity negative regulation of microtubule nucleation negative regulation of microtubule plus-end binding negative regulation of microtubule polymerization negative regulation of microtubule polymerization or depolymerization negative regulation of microvillus assembly negative regulation of midbrain dopaminergic neuron differentiation negative regulation of mineralocorticoid secretion negative regulation of mini excitatory postsynaptic potential negative regulation of miRNA catabolic process negative regulation of miRNA mediated inhibition of translation negative regulation of miRNA metabolic process negative regulation of mismatch repair negative regulation of mitochondrial ATP synthesis coupled electron transport negative regulation of mitochondrial ATP synthesis coupled proton transport negative regulation of mitochondrial depolarization negative regulation of mitochondrial DNA metabolic process negative regulation of mitochondrial DNA replication negative regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of mitochondrial fission negative regulation of mitochondrial fusion negative regulation of mitochondrial mRNA catabolic process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of mitochondrial RNA catabolic process negative regulation of mitochondrial translation negative regulation of mitochondrial translational elongation negative regulation of mitochondrial translational initiation negative regulation of mitochondrion organization negative regulation of mitophagy negative regulation of mitotic actomyosin contractile ring assembly negative regulation of mitotic actomyosin contractile ring contraction negative regulation of mitotic cell cycle negative regulation of mitotic cell cycle DNA replication negative regulation of mitotic cell cycle phase transition negative regulation of mitotic cell cycle, embryonic negative regulation of mitotic centrosome separation negative regulation of mitotic chromosome condensation negative regulation of mitotic cohesin loading negative regulation of mitotic cytokinesis negative regulation of mitotic cytokinetic process negative regulation of mitotic DNA damage checkpoint negative regulation of mitotic DNA replication initiation negative regulation of mitotic metaphase/anaphase transition negative regulation of mitotic nuclear division negative regulation of mitotic nuclear envelope disassembly negative regulation of mitotic recombination negative regulation of mitotic sister chromatid arm separation negative regulation of mitotic sister chromatid segregation negative regulation of mitotic sister chromatid separation negative regulation of mitotic spindle elongation negative regulation of mitotic spindle pole body separation negative regulation of mitotic telomere tethering at nuclear periphery negative regulation of molecular function negative regulation of monocyte aggregation negative regulation of monocyte antigen processing and presentation negative regulation of monocyte chemotactic protein-1 production negative regulation of monocyte chemotaxis negative regulation of monocyte differentiation negative regulation of monocyte extravasation negative regulation of monodictyphenone biosynthetic process negative regulation of mononuclear cell migration negative regulation of mononuclear cell proliferation negative regulation of monooxygenase activity negative regulation of monophenol monooxygenase activity negative regulation of monopolar cell growth negative regulation of morphogenesis of an epithelium negative regulation of motile cilium assembly negative regulation of motor neuron apoptotic process negative regulation of motor neuron axon guidance negative regulation of motor neuron migration negative regulation of mRNA 3'-end processing negative regulation of mRNA 3'-UTR binding negative regulation of mRNA binding negative regulation of mRNA cap binding negative regulation of mRNA catabolic process negative regulation of mRNA cis splicing, via spliceosome negative regulation of mRNA cleavage negative regulation of mRNA metabolic process negative regulation of mRNA modification negative regulation of mRNA polyadenylation negative regulation of mRNA processing negative regulation of mRNA splicing, via spliceosome negative regulation of mucus secretion negative regulation of multi-organism process negative regulation of multicellular organism growth negative regulation of multicellular organismal process negative regulation of muscle adaptation negative regulation of muscle atrophy negative regulation of muscle cell apoptotic process negative regulation of muscle cell chemotaxis toward tendon cell negative regulation of muscle cell differentiation negative regulation of muscle contraction negative regulation of muscle filament sliding negative regulation of muscle hyperplasia negative regulation of muscle hypertrophy negative regulation of muscle organ development negative regulation of muscle tissue development negative regulation of MyD88-dependent toll-like receptor signaling pathway negative regulation of MyD88-independent toll-like receptor signaling pathway negative regulation of myelination negative regulation of myeloid cell apoptotic process negative regulation of myeloid cell differentiation negative regulation of myeloid dendritic cell activation negative regulation of myeloid dendritic cell antigen processing and presentation negative regulation of myeloid dendritic cell chemotaxis negative regulation of myeloid dendritic cell cytokine production negative regulation of myeloid leukocyte differentiation negative regulation of myeloid leukocyte mediated immunity negative regulation of myeloid progenitor cell differentiation negative regulation of myoblast differentiation negative regulation of myoblast fusion negative regulation of myoblast proliferation negative regulation of myofibroblast cell apoptotic process negative regulation of myofibroblast contraction negative regulation of myofibroblast differentiation negative regulation of myosin II filament assembly negative regulation of myosin II filament organization negative regulation of myosin light chain kinase activity negative regulation of myosin-light-chain-phosphatase activity negative regulation of myotube differentiation negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process negative regulation of N-terminal peptidyl-lysine acetylation negative regulation of N-terminal peptidyl-methionine acetylation negative regulation of N-terminal protein palmitoylation negative regulation of NAD metabolic process negative regulation of NAD(P)H oxidase activity negative regulation of NAD+ ADP-ribosyltransferase activity negative regulation of NAD+ kinase activity negative regulation of naphtho-gamma-pyrone biosynthetic process negative regulation of natural killer cell activation negative regulation of natural killer cell apoptotic process negative regulation of natural killer cell chemotaxis negative regulation of natural killer cell cytokine production negative regulation of natural killer cell degranulation negative regulation of natural killer cell differentiation negative regulation of natural killer cell differentiation involved in immune response negative regulation of natural killer cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of natural killer cell mediated immune response to tumor cell negative regulation of natural killer cell mediated immunity negative regulation of natural killer cell proliferation negative regulation of natural killer cell proliferation involved in immune response negative regulation of natural killer cell tolerance induction negative regulation of ncRNA transcription associated with protein coding gene TSS/TES negative regulation of necroptotic process negative regulation of necrotic cell death negative regulation of negative chemotaxis negative regulation of nematode larval development negative regulation of nematode male tail tip morphogenesis negative regulation of neosartoricin biosynthetic process negative regulation of nephron tubule epithelial cell differentiation negative regulation of nerve growth factor production negative regulation of nerve growth factor receptor activity negative regulation of nervous system development negative regulation of nervous system process negative regulation of netrin-activated signaling pathway negative regulation of neural crest cell differentiation negative regulation of neural crest cell fate specification negative regulation of neural crest formation negative regulation of neural precursor cell proliferation negative regulation of neural retina development negative regulation of neuroblast migration negative regulation of neuroblast proliferation negative regulation of neurofibrillary tangle assembly negative regulation of neurogenesis negative regulation of neuromuscular junction development negative regulation of neuromuscular synaptic transmission negative regulation of neuron apoptotic process negative regulation of neuron death negative regulation of neuron differentiation negative regulation of neuron maturation negative regulation of neuron migration negative regulation of neuron projection arborization negative regulation of neuron projection development negative regulation of neuron projection regeneration negative regulation of neuron remodeling negative regulation of neuronal action potential negative regulation of neuronal signal transduction negative regulation of neurotransmitter secretion negative regulation of neurotransmitter transport negative regulation of neurotransmitter uptake negative regulation of neurotrophin production negative regulation of neurotrophin TRK receptor signaling pathway negative regulation of neutrophil activation negative regulation of neutrophil aggregation negative regulation of neutrophil apoptotic process negative regulation of neutrophil chemotaxis negative regulation of neutrophil degranulation negative regulation of neutrophil differentiation negative regulation of neutrophil extravasation negative regulation of neutrophil mediated cytotoxicity negative regulation of neutrophil mediated killing of bacterium negative regulation of neutrophil mediated killing of fungus negative regulation of neutrophil mediated killing of gram-negative bacterium negative regulation of neutrophil mediated killing of gram-positive bacterium negative regulation of neutrophil mediated killing of symbiont cell negative regulation of neutrophil migration negative regulation of nigerotriose transport negative regulation of NIK/NF-kappaB signaling negative regulation of nitric oxide biosynthetic process negative regulation of nitric oxide mediated signal transduction negative regulation of nitric oxide metabolic process negative regulation of nitric-oxide synthase activity negative regulation of nitric-oxide synthase biosynthetic process negative regulation of nitrogen compound metabolic process negative regulation of nitrogen cycle metabolic process negative regulation of nitrogen utilization negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway negative regulation of NK T cell activation negative regulation of NK T cell differentiation negative regulation of NK T cell proliferation negative regulation of NLRP3 inflammasome complex assembly negative regulation of NMDA glutamate receptor activity negative regulation of NMS complex assembly negative regulation of nodal receptor complex assembly negative regulation of nodal signaling pathway negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of nodal signaling pathway involved in determination of left/right asymmetry negative regulation of non-canonical Wnt signaling pathway negative regulation of non-canonical Wnt signaling pathway via JNK cascade negative regulation of non-membrane spanning protein tyrosine kinase activity negative regulation of non-motile cilium assembly negative regulation of non-professional antigen presenting cell antigen processing and presentation negative regulation of nonadec-1-ene biosynthetic process negative regulation of nonadec-1-ene metabolic process negative regulation of norepinephrine secretion negative regulation of norepinephrine uptake negative regulation of Notch signaling pathway negative regulation of Notch signaling pathway involved in somitogenesis negative regulation of nuclear cell cycle DNA replication negative regulation of nuclear division negative regulation of nuclear migration along microtubule negative regulation of nuclear migration during mitotic telophase negative regulation of nuclear receptor transcription coactivator activity negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of nuclease activity negative regulation of nucleic acid-templated transcription negative regulation of nucleobase-containing compound metabolic process negative regulation of nucleobase-containing compound transport negative regulation of nucleocytoplasmic transport negative regulation of nucleoside metabolic process negative regulation of nucleoside transport negative regulation of nucleotide biosynthetic process negative regulation of nucleotide catabolic process negative regulation of nucleotide metabolic process negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing signaling pathway negative regulation of nurse cell apoptotic process negative regulation of o-orsellinic acid biosynthetic process negative regulation of octadecene biosynthetic process negative regulation of octadecene metabolic process negative regulation of octopamine or tyramine signaling pathway negative regulation of octopamine signaling pathway negative regulation of octopamine signaling pathway involved in response to food negative regulation of odontoblast differentiation negative regulation of odontogenesis negative regulation of odontogenesis of dentin-containing tooth negative regulation of olefin biosynthetic process negative regulation of olefin metabolic process negative regulation of oligodendrocyte apoptotic process negative regulation of oligodendrocyte differentiation negative regulation of oligodendrocyte progenitor proliferation negative regulation of oligopeptide transport negative regulation of oocyte development negative regulation of oocyte maturation negative regulation of oogenesis negative regulation of oogonium development negative regulation of oomycete sporangium development negative regulation of oospore formation negative regulation of opioid receptor signaling pathway negative regulation of optic nerve formation negative regulation of optical nerve axon regeneration negative regulation of orcinol biosynthetic process negative regulation of organ growth negative regulation of organelle assembly negative regulation of organelle organization negative regulation of organic acid transport negative regulation of ornithine catabolic process negative regulation of osmolarity-sensing cation channel activity negative regulation of osmosensory signaling pathway negative regulation of ossification negative regulation of osteoblast differentiation negative regulation of osteoblast proliferation negative regulation of osteoclast development negative regulation of osteoclast differentiation negative regulation of osteoclast proliferation negative regulation of otic vesicle morphogenesis negative regulation of outer hair cell apoptotic process negative regulation of ovarian follicle development negative regulation of oviposition negative regulation of ovulation negative regulation of oxidative phosphorylation negative regulation of oxidative phosphorylation uncoupler activity negative regulation of oxidative stress-induced cell death negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidoreductase activity negative regulation of oxygen metabolic process negative regulation of p38MAPK cascade negative regulation of pancreatic A cell differentiation negative regulation of pancreatic amylase secretion negative regulation of pancreatic juice secretion negative regulation of pancreatic stellate cell proliferation negative regulation of pancreatic trypsinogen secretion negative regulation of parathyroid hormone secretion negative regulation of paraxial mesodermal cell fate determination negative regulation of paraxial mesodermal cell fate specification negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization negative regulation of pathway-restricted SMAD protein phosphorylation negative regulation of pectin catabolic process negative regulation of penicillin biosynthetic process negative regulation of penicillin catabolic process negative regulation of penicillin metabolic process negative regulation of penile erection negative regulation of pentadecane biosynthetic process negative regulation of pentadecane metabolic process negative regulation of pentasaccharide transport negative regulation of pentose catabolic process to ethanol negative regulation of pentose-phosphate shunt negative regulation of peptidase activity negative regulation of peptide antigen transport negative regulation of peptide hormone processing negative regulation of peptide hormone secretion negative regulation of peptide secretion negative regulation of peptidoglycan recognition protein signaling pathway negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of peptidyl-L-cysteine S-palmitoylation negative regulation of peptidyl-lysine acetylation negative regulation of peptidyl-lysine crotonylation negative regulation of peptidyl-serine dephosphorylation negative regulation of peptidyl-serine phosphorylation negative regulation of peptidyl-serine phosphorylation of STAT protein negative regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of peptidyl-tyrosine phosphorylation negative regulation of peripheral B cell anergy negative regulation of peripheral B cell deletion negative regulation of peripheral T cell tolerance induction negative regulation of peripheral tolerance induction negative regulation of PERK-mediated unfolded protein response negative regulation of peroxidase activity negative regulation of peroxisome proliferator activated receptor signaling pathway negative regulation of phagocytosis negative regulation of phagocytosis, engulfment negative regulation of phagosome maturation negative regulation of pharyngeal pumping negative regulation of pharynx morphogenesis negative regulation of phenazine biosynthetic process negative regulation of phenotypic switching negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion negative regulation of phialide development negative regulation of phosphatase activity negative regulation of phosphate metabolic process negative regulation of phosphate transmembrane transport negative regulation of phosphatidate phosphatase activity negative regulation of phosphatidic acid biosynthetic process negative regulation of phosphatidylcholine biosynthetic process negative regulation of phosphatidylcholine catabolic process negative regulation of phosphatidylglycerol biosynthetic process negative regulation of phosphatidylinositol 3-kinase activity negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of phosphatidylinositol biosynthetic process negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity negative regulation of phosphatidylserine biosynthetic process negative regulation of phosphatidylserine exposure on apoptotic cell surface negative regulation of phospholipase A2 activity negative regulation of phospholipase activity negative regulation of phospholipase C activity negative regulation of phospholipase C-activating dopamine receptor signaling pathway negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway negative regulation of phospholipase D activity negative regulation of phospholipid biosynthetic process negative regulation of phospholipid efflux negative regulation of phospholipid metabolic process negative regulation of phospholipid scramblase activity negative regulation of phospholipid translocation negative regulation of phospholipid transport negative regulation of phosphoprotein phosphatase activity negative regulation of phosphorelay signal transduction system negative regulation of phosphorus metabolic process negative regulation of phosphorus utilization negative regulation of phosphorylation negative regulation of phosphorylation of RNA polymerase II C-terminal domain negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues negative regulation of photomorphogenesis negative regulation of photoreceptor cell differentiation negative regulation of photosynthesis negative regulation of photosynthesis, light reaction negative regulation of phytoalexin biosynthetic process negative regulation of phytoalexin metabolic process negative regulation of pigment cell differentiation negative regulation of pinocytosis negative regulation of planar cell polarity pathway involved in axis elongation negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis negative regulation of planar cell polarity pathway involved in heart morphogenesis negative regulation of planar cell polarity pathway involved in neural tube closure negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis negative regulation of planar cell polarity pathway involved in pericardium morphogenesis negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis negative regulation of plant epidermal cell differentiation negative regulation of plant organ morphogenesis negative regulation of plant-type cell wall cellulose biosynthetic process negative regulation of plant-type cell wall cellulose catabolic process negative regulation of plant-type hypersensitive response negative regulation of plasma cell differentiation negative regulation of plasma kallikrein-kinin cascade negative regulation of plasma lipoprotein oxidation negative regulation of plasma membrane bounded cell projection assembly negative regulation of plasma membrane raft polarization negative regulation of plasma membrane repair negative regulation of plasmacytoid dendritic cell antigen processing and presentation negative regulation of plasmacytoid dendritic cell cytokine production negative regulation of plasmatocyte differentiation negative regulation of plasminogen activation negative regulation of platelet activation negative regulation of platelet aggregation negative regulation of platelet formation negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of plus-end directed microfilament motor activity negative regulation of podosome assembly negative regulation of polarized epithelial cell differentiation negative regulation of pole plasm oskar mRNA localization negative regulation of polyamine transmembrane transport negative regulation of polyketide biosynthetic process negative regulation of polynucleotide adenylyltransferase activity negative regulation of polysome binding negative regulation of positive chemotaxis negative regulation of positive thymic T cell selection negative regulation of post-embryonic development negative regulation of post-translational protein modification negative regulation of postsynaptic density organization negative regulation of postsynaptic membrane organization negative regulation of posttranscriptional gene silencing negative regulation of potassium ion export across plasma membrane negative regulation of potassium ion import across plasma membrane negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transport negative regulation of potassium:proton exchanging ATPase activity negative regulation of pre-miRNA processing negative regulation of preblastoderm mitotic cell cycle negative regulation of premature acrosome loss negative regulation of presynapse assembly negative regulation of presynaptic active zone assembly negative regulation of presynaptic membrane organization negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of primary amine oxidase activity negative regulation of primary cell septum biogenesis negative regulation of primary miRNA processing negative regulation of pro-B cell differentiation negative regulation of pro-T cell differentiation negative regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of production of molecular mediator of immune response negative regulation of production of siRNA involved in RNA interference negative regulation of progesterone biosynthetic process negative regulation of progesterone secretion negative regulation of programmed cell death negative regulation of programmed necrotic cell death negative regulation of prolactin secretion negative regulation of prolactin signaling pathway negative regulation of proline biosynthetic process negative regulation of proline catabolic process to glutamate negative regulation of proline import across plasma membrane negative regulation of proline metabolic process negative regulation of pronephric nephron tubule development negative regulation of prostaglandin biosynthetic process negative regulation of prostaglandin catabolic process negative regulation of prostaglandin secretion negative regulation of prostaglandin-E synthase activity negative regulation of prostatic bud formation negative regulation of prosthetic group metabolic process negative regulation of proteasomal protein catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of proteasome-activating ATPase activity negative regulation of protection from non-homologous end joining at telomere negative regulation of protein acetylation negative regulation of protein activation cascade negative regulation of protein adenylylation negative regulation of protein ADP-ribosylation negative regulation of protein autophosphorylation negative regulation of protein autoubiquitination negative regulation of protein binding negative regulation of protein catabolic process negative regulation of protein catabolic process in the vacuole negative regulation of protein complex assembly negative regulation of protein complex disassembly negative regulation of protein dephosphorylation negative regulation of protein depolymerization negative regulation of protein desumoylation negative regulation of protein deubiquitination negative regulation of protein exit from endoplasmic reticulum negative regulation of protein export from nucleus negative regulation of protein folding negative regulation of protein geranylgeranylation negative regulation of protein glutathionylation negative regulation of protein glycosylation negative regulation of protein glycosylation in Golgi negative regulation of protein histidine kinase activity negative regulation of protein homodimerization activity negative regulation of protein homooligomerization negative regulation of protein homotetramerization negative regulation of protein import negative regulation of protein import into mitochondrial outer membrane negative regulation of protein import into nucleus negative regulation of protein K48-linked deubiquitination negative regulation of protein K48-linked ubiquitination negative regulation of protein K63-linked deubiquitination negative regulation of protein K63-linked ubiquitination negative regulation of protein kinase activity negative regulation of protein kinase B signaling negative regulation of protein kinase C signaling negative regulation of protein kinase D signaling negative regulation of protein linear polyubiquitination negative regulation of protein lipidation negative regulation of protein localization to actin cortical patch negative regulation of protein localization to basolateral plasma membrane negative regulation of protein localization to Cajal body negative regulation of protein localization to cell cortex negative regulation of protein localization to cell leading edge negative regulation of protein localization to cell periphery negative regulation of protein localization to cell surface negative regulation of protein localization to cell tip negative regulation of protein localization to cell-cell adherens junction negative regulation of protein localization to centrosome negative regulation of protein localization to chromatin negative regulation of protein localization to chromosome, telomeric region negative regulation of protein localization to ciliary membrane negative regulation of protein localization to cilium negative regulation of protein localization to endoplasmic reticulum negative regulation of protein localization to endosome negative regulation of protein localization to kinetochore negative regulation of protein localization to membrane negative regulation of protein localization to microtubule negative regulation of protein localization to mitotic spindle pole body negative regulation of protein localization to non-growing cell tip negative regulation of protein localization to nucleolus negative regulation of protein localization to nucleus negative regulation of protein localization to phagocytic vesicle negative regulation of protein localization to plasma membrane negative regulation of protein localization to presynapse negative regulation of protein localization to spindle pole body negative regulation of protein maturation negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal negative regulation of protein modification process negative regulation of protein monoubiquitination negative regulation of protein neddylation negative regulation of protein O-linked glycosylation negative regulation of protein oligomerization negative regulation of protein oxidation negative regulation of protein phosphorylation negative regulation of protein polyglycylation negative regulation of protein polymerization negative regulation of protein polyubiquitination negative regulation of protein processing negative regulation of protein processing in phagocytic vesicle negative regulation of protein processing involved in protein targeting to mitochondrion negative regulation of protein refolding negative regulation of protein secretion negative regulation of protein serine/threonine kinase activity negative regulation of protein serine/threonine phosphatase activity negative regulation of protein sumoylation negative regulation of protein targeting to membrane negative regulation of protein targeting to mitochondrion negative regulation of protein targeting to vacuolar membrane negative regulation of protein targeting to vacuole involved in autophagy negative regulation of protein tetramerization negative regulation of protein transport negative regulation of protein tyrosine kinase activity negative regulation of protein tyrosine phosphatase activity negative regulation of protein ubiquitination negative regulation of protein-pyridoxal-5-phosphate linkage negative regulation of proteinase activated receptor activity negative regulation of proteoglycan biosynthetic process negative regulation of proteolysis negative regulation of proteolysis associated with antigen processing and presentation negative regulation of proteolysis involved in cellular protein catabolic process negative regulation of proton-transporting ATP synthase activity, rotational mechanism negative regulation of pseudohyphal growth negative regulation of pseudopodium assembly negative regulation of pseurotin A biosynthetic process negative regulation of pteridine metabolic process negative regulation of pulmonary blood vessel remodeling negative regulation of pupariation negative regulation of purine nucleobase metabolic process negative regulation of purine nucleotide biosynthetic process negative regulation of purine nucleotide catabolic process negative regulation of purine nucleotide metabolic process negative regulation of pyloric antrum smooth muscle contraction negative regulation of pyrimidine nucleobase metabolic process negative regulation of pyrimidine nucleotide biosynthetic process negative regulation of pyruvate dehydrogenase activity negative regulation of pyruvate kinase activity negative regulation of quinolinate biosynthetic process negative regulation of R7 cell differentiation negative regulation of R8 cell differentiation negative regulation of Rac protein signal transduction negative regulation of raffinose biosynthetic process negative regulation of Ran protein signal transduction negative regulation of Ras GTPase binding negative regulation of Ras protein signal transduction negative regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of receptor binding negative regulation of receptor biosynthetic process negative regulation of receptor catabolic process negative regulation of receptor clustering negative regulation of receptor internalization negative regulation of receptor localization to synapse negative regulation of receptor recycling negative regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via STAT negative regulation of receptor-mediated endocytosis negative regulation of receptor-mediated endocytosis involved in cholesterol transport negative regulation of receptor-mediated virion attachment to host cell negative regulation of reciprocal meiotic recombination negative regulation of red or far-red light signaling pathway negative regulation of regulated secretory pathway negative regulation of regulation of vascular smooth muscle cell membrane depolarization negative regulation of regulatory T cell differentiation negative regulation of relaxation of cardiac muscle negative regulation of relaxation of muscle negative regulation of relaxation of smooth muscle negative regulation of release of cytochrome c from mitochondria negative regulation of release of sequestered calcium ion into cytosol negative regulation of removal of superoxide radicals negative regulation of renal albumin absorption negative regulation of renal amino acid absorption negative regulation of renal phosphate excretion negative regulation of renal sodium excretion negative regulation of renal water transport negative regulation of renin secretion into blood stream negative regulation of replicative senescence negative regulation of reproductive process negative regulation of respiratory burst negative regulation of respiratory burst involved in inflammatory response negative regulation of respiratory gaseous exchange negative regulation of response to acetate negative regulation of response to alcohol negative regulation of response to amylopectin negative regulation of response to benzene negative regulation of response to biotic stimulus negative regulation of response to butan-1-ol negative regulation of response to cycloalkane negative regulation of response to cytokine stimulus negative regulation of response to DNA damage stimulus negative regulation of response to drug negative regulation of response to endoplasmic reticulum stress negative regulation of response to ethanol negative regulation of response to external stimulus negative regulation of response to extracellular stimulus negative regulation of response to food negative regulation of response to formic acid negative regulation of response to furfural negative regulation of response to gamma radiation negative regulation of response to interferon-gamma negative regulation of response to macrophage colony-stimulating factor negative regulation of response to nutrient levels negative regulation of response to oxidative stress negative regulation of response to propan-1-ol negative regulation of response to pullulan negative regulation of response to reactive oxygen species negative regulation of response to salt stress negative regulation of response to stimulus negative regulation of response to toluene negative regulation of response to tumor cell negative regulation of response to wounding negative regulation of restriction endodeoxyribonuclease activity negative regulation of retina development in camera-type eye negative regulation of retinal cell programmed cell death negative regulation of retinal cone cell fate commitment negative regulation of retinal cone cell fate specification negative regulation of retinoic acid biosynthetic process negative regulation of retinoic acid receptor signaling pathway negative regulation of retrograde axon cargo transport negative regulation of retrograde dense core granule transport negative regulation of retrograde protein transport, ER to cytosol negative regulation of retrograde trans-synaptic signaling by neuropeptide negative regulation of retrograde transport, endosome to Golgi negative regulation of reverse cholesterol transport negative regulation of reverse transcription negative regulation of Rho guanyl-nucleotide exchange factor activity negative regulation of Rho protein signal transduction negative regulation of Rho-dependent protein serine/threonine kinase activity negative regulation of ribonuclease activity negative regulation of ribonucleoprotein complex localization negative regulation of ribosomal large subunit export from nucleus negative regulation of ribosomal small subunit export from nucleus negative regulation of ribosomal subunit export from nucleus negative regulation of ribosome biogenesis negative regulation of RIG-I signaling pathway negative regulation of ripoptosome assembly involved in necroptotic process negative regulation of RNA binding negative regulation of RNA binding transcription factor activity negative regulation of RNA biosynthetic process negative regulation of RNA catabolic process negative regulation of RNA export from nucleus negative regulation of RNA helicase activity negative regulation of RNA import into nucleus negative regulation of RNA interference negative regulation of RNA metabolic process negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding negative regulation of RNA polymerase II transcriptional preinitiation complex assembly negative regulation of RNA polymerase III activity negative regulation of RNA splicing negative regulation of RNA-directed 5'-3' RNA polymerase activity negative regulation of root hair elongation negative regulation of Roundabout signaling pathway negative regulation of rRNA processing negative regulation of ruffle assembly negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of saliva secretion negative regulation of salivary gland boundary specification negative regulation of sarcinapterin biosynthetic process negative regulation of sarcinapterin metabolic process negative regulation of sarcomere organization negative regulation of satellite cell differentiation negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process negative regulation of Schwann cell chemotaxis negative regulation of Schwann cell differentiation negative regulation of Schwann cell migration negative regulation of Schwann cell proliferation negative regulation of Schwann cell proliferation involved in axon regeneration negative regulation of sclerotium development negative regulation of sebum secreting cell proliferation negative regulation of secondary cell septum biogenesis negative regulation of secondary cell wall biogenesis negative regulation of secondary growth negative regulation of secondary metabolite biosynthetic process negative regulation of secretion negative regulation of secretion by cell negative regulation of secretion of lysosomal enzymes negative regulation of secretory granule organization negative regulation of seed dormancy process negative regulation of seed germination