Term Name: CGP 78608
Synonyms: [(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid
Definition: A phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.
Ontology: ChEBI [CHEBI:64061]  ( EBI )

Relationships
is a type of: organobromine compound phosphonic acids quinoxaline derivative secondary amino compound
has_part: CGP 78608(1+)
has_role: anticonvulsant NMDA receptor antagonist