Term Name: plinabulin
Synonyms: (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, BPI 2358, BPI-2358, NPI 2358, NPI-2358, NPI2358, plinabulin, plinabulina, plinabuline, plinabulinum
Definition: A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione substituted by benzylidene and (5-tert-butyl-1H-imidazol-4-yl)methylidene groups at positions 3 and 6, respectively. It is a vascular disrupting agent and a microtubule destabalising agent which was in clinical trials (now discontinued) for the treatment of non-small cell lung cancer.
Ontology: ChEBI [CHEBI:177413]  ( EBI )

Relationships
is a type of: 2,5-diketopiperazines benzenes imidazoles olefinic compound
has_role: angiogenesis inhibitor antineoplastic agent apoptosis inducer microtubule-destabilising agent