| Synonyms: |
6-acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one,
acetopyrrothin,
acetopyrrothine,
N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide,
N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide,
N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
|
| Definition: |
A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases. |