ZFIN ID: ZDB-GENE-990415-30
Gene Name: activated leukocyte cell adhesion molecule a
Gene Symbol: alcama
Previous Names: alcam (1), cd166 (1), DM-GRASP (1), neurolin-a (1), neurolin (1), zn5 / zn-5 antigen (1), zn8 / zn-8 antigen
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 161 figures from 91 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2004 [MGC:55230]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  abducens motor nucleus, adaxial cell, anterior commissure, atrioventricular canal endocardium (all 105) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
la011841Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12510 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-alcama (1), MO2-alcama (1), MO3-alcama (1), MO4-alcama (1), MO5-alcama (1)
    PHENOTYPE
    Data: 6 figures from 4 publications
    Observed in: ceratohyal cartilage, eye, heart looping, hyosymplectic cartilage (all 14) expand
    DISEASE ASSOCIATED WITH alcama HUMAN ORTHOLOG No data available
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component axon (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003006 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013106 (1)
  • InterPro:IPR013162 (1)
  • InterPro:IPR013783 (1)
  • PROSITE:PS00290 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF08205 (1)
  • Pfam:PF13895 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA alcama-001 (1) 3112
    ottdart00000004183 (1) 1145
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-alcama (1), Ab2-alcama (1), Ab3-alcama (1), zn-5 (1), zn-8 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alcama
    Tg(nkx2.3:alcama-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    alcamaContained in: [BAC] DKEY-222J15 (1) (order this)
    [PAC] BUSM1-17K08 (1) (order this), BUSM1-25N23 (1) (order this), BUSM1-39L02 (1) (order this), BUSM1-71O15 (1) (order this)
    alcamaEncodes: [cDNA] cssl:d215 (1), cssl:d822 (1), MGC:55230 (1) (order this), MGC:85602 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131000 (1) 2057bp
    Genomic GenBank:BX537347 (1) 197064bp
    Select Tool
    Polypeptide UniProtKB:F1Q742 (1) 564aa
    Sequence Clusters UniGene:20912 (1)
    Sequence Information (all 43)
    OTHER alcama GENE PAGES 
  • Gene:30194 (1)
  • VEGA:OTTDARG00000004010 (1)
  • VEGA:OTTDARG00000008167 (1)
  • Ensembl(GRCz10):ENSDARG00000026531 (1)
  • ORTHOLOGY for alcama (Chr: 10) 
    Species Symbol Chromosome Accession # Evidence
    Human ALCAM 3
  • Gene:214
  • OMIM:601662
  • HGNC:400
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Alcam 16
  • MGI:1313266
  • Gene:11658
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (142)