Gene
shrprbck1r
- ID
- ZDB-GENE-080220-52
- Name
- sharpin and rbck1 related
- Symbol
- shrprbck1r Nomenclature History
- Previous Names
-
- sipl1-rbck1 (1)
- zgc:175152
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin binding activity and ubiquitin-protein transferase activity. Involved in embryonic cranial skeleton morphogenesis and otic vesicle morphogenesis. Predicted to localize to LUBAC complex. Is expressed in inner ear; midbrain hindbrain boundary; otic vesicle; and pharyngeal arch. Orthologous to human SHARPIN (SHANK associated RH domain interactor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Landgraf et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Landgraf et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Domain | IPR031912 | Sharpin, PH domain |
| Domain | IPR044066 | TRIAD supradomain |
| Domain | IPR047557 | Heme-oxidized IRP2 ubiquitin ligase 1, Rcat domain |
| Domain | IPR047558 | Heme-oxidized IRP2 ubiquitin ligase 1, BRcat domain |
| Domain | IPR047559 | Heme-oxidized IRP2 ubiquitin ligase 1, modified RING finger, HC subclass |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
Domain Details Per Protein
| Protein | Length | Heme-oxidized IRP2 ubiquitin ligase 1, BRcat domain | Heme-oxidized IRP2 ubiquitin ligase 1, modified RING finger, HC subclass | Heme-oxidized IRP2 ubiquitin ligase 1, Rcat domain | PH-like domain superfamily | Sharpin, PH domain | TRIAD supradomain | Ubiquitin-like domain superfamily | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9JTG5
|
714 | ||||||||||||
|
UniProtKB:A0A1D5NSY4
|
478 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
shrprbck1r-201
(1)
|
Havana | 4393 nt | |
| mRNA |
shrprbck1r-202
(1)
|
Havana | 3884 nt |
Interactions and Pathways
No data available
Plasmids
No data available