Gene

mcf2lb

ID

ZDB-GENE-081104-416

Name

mcf.2 cell line derived transforming sequence-like b

Symbol

mcf2lb Nomenclature History

Previous Names

sb:eu830
si:dkey-46k9.10

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction. Is expressed in lateral line system; otic placode; and otic vesicle. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu830 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcf2lb Human Ortholog

No data available

Associated With mcf2lb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR001849	Pleckstrin homology domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Repeat	IPR018159	Spectrin/alpha-actinin

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	Spectrin/alpha-actinin
UniProtKB:A0A8N7T881 InterPro	1093
UniProtKB:A0A8M9Q556 InterPro	1088
UniProtKB:A0A8M9Q336 InterPro	1095
UniProtKB:A0A8M9QBG1 InterPro	1072
UniProtKB:A0A8M9QK90 InterPro	1097

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mcf2lb-202 (1) Ensembl	Havana	1543 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mcf2lb-203 (1) Ensembl	Havana	1507 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations