Gene

cox10

ID

ZDB-GENE-041111-239

Name

cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

Symbol

cox10 Nomenclature History

Previous Names

im:7145568
im:7157205
wu:fb18a03

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have farnesyltranstransferase activity. Predicted to be involved in cellular respiration and heme biosynthetic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Leigh disease and cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7145568 (1 image)
IMAGE:7157205 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cox10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial complex IV deficiency nuclear type 3	Alliance	Mitochondrial complex IV deficiency, nuclear type 3	619046

Associated With cox10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030470	UbiA prenyltransferase conserved site
Family	IPR000537	UbiA prenyltransferase family
Family	IPR006369	Protohaem IX farnesyltransferase
Family	IPR016315	Protohaem IX farnesyltransferase, mitochondria
Homologous_superfamily	IPR044878	UbiA prenyltransferase superfamily