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General Information
ZIRC
ZFIN ID: ZDB-GENE-990630-10
Gene Name: lefty1
Gene Symbol: lft1
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function cytokine activity IBA UniProtKB:P08476, PANTHER:PTN000218063, UniProtKB:P12644 Gaudet et al., 2010
cytokine activity IEA UniProtKB-KW:KW-0202 ZFIN Electronic Annotation
growth factor activity IEA UniRule:UR000640755 UniProt curators
growth factor activity IEA InterPro:IPR001839 ZFIN Electronic Annotation
growth factor activity IEA InterPro:IPR017948 ZFIN Electronic Annotation
growth factor activity IEA UniProtKB-KW:KW-0339 ZFIN Electronic Annotation
transforming growth factor beta receptor binding IBA PANTHER:PTN000218063, UniProtKB:P61812, MGI:MGI:98725 Gaudet et al., 2010
transforming growth factor beta receptor binding IEA InterPro:IPR003942 ZFIN Electronic Annotation
Cellular Component extracellular region IEA UniProtKB-KW:KW-0964 ZFIN Electronic Annotation
extracellular space IBA RGD:2213, RGD:2212, RGD:2214, UniProtKB:P18075, RGD:2211, MGI:MGI:98726, UniProtKB:Q96S42, MGI:MGI:98725, UniProtKB:P12644, RGD:69051, UniProtKB:P12643, UniProtKB:Q99988, RGD:70491, RGD:62074, MGI:MGI:103302, PANTHER:PTN000218063, RGD:2913, RGD:620743, MGI:MGI:88177, RGD:621512, WB:WBGene00000903, RGD:2912, UniProtKB:P01137, RGD:3115, RGD:3851, UniProtKB:O14793, RGD:1305979, MGI:MGI:95691, MGI:MGI:88180, UniProtKB:O95393, FB:FBgn0000490, MGI:MGI:1338027, UniProtKB:P61812, UniProtKB:O42220 Gaudet et al., 2010
extracellular space IEA UniProtKB-KW:KW-0202 ZFIN Electronic Annotation
Biological Process BMP signaling pathway IBA MGI:MGI:88180, UniProtKB:O95393, PANTHER:PTN000218210, MGI:MGI:95690, RGD:2211, UniProtKB:Q7Z4P5, MGI:MGI:95689, MGI:MGI:88177, UniProtKB:P12644, UniProtKB:Q9UK05, UniProtKB:P12643, UniProtKB:Q6KF10 Gaudet et al., 2010
cell development IBA MGI:MGI:103302, PANTHER:PTN000218063 Gaudet et al., 2010
determination of heart left/right asymmetry IMP MO1-lft1 Lenhart et al., 2011
determination of heart left/right asymmetry IMP MO4-lft1 Smith et al., 2011
determination of left/right asymmetry in diencephalon IMP MO1-lft1 Lenhart et al., 2011
determination of left/right asymmetry in lateral mesoderm IMP MO1-lft1 Lenhart et al., 2011
determination of left/right symmetry IMP MO2-lft1 Wang et al., 2008
dorsal/ventral pattern formation IDA Shimizu et al., 2000
embryonic heart tube development IMP Keegan et al., 2004
mesoderm development IMP lft1a145/a145 ; lft2a146/a146 Rogers et al., 2017
multicellular organism development IEA UniProtKB-KW:KW-0217 ZFIN Electronic Annotation
positive regulation of pathway-restricted SMAD protein phosphorylation IBA MGI:MGI:107335, UniProtKB:P18075, UniProtKB:P22003, UniProtKB:Q7Z4P5, MGI:MGI:98727, UniProtKB:Q96S42, UniProtKB:P12644, MGI:MGI:95684, UniProtKB:P12643, UniProtKB:Q6KF10, UniProtKB:O95393, MGI:MGI:88182, UniProtKB:P08476, MGI:MGI:1338820, PANTHER:PTN000218063, UniProtKB:P22004, UniProtKB:Q9UK05, UniProtKB:P01137 Gaudet et al., 2010
regulation of apoptotic process IBA MGI:MGI:98726, PANTHER:PTN000218063 Gaudet et al., 2010
regulation of MAPK cascade IBA MGI:MGI:107335, PANTHER:PTN000218063 Gaudet et al., 2010
SMAD protein signal transduction IBA UniProtKB:P18075, MGI:MGI:95689, UniProtKB:P12644, UniProtKB:P12643, MGI:MGI:97359, UniProtKB:Q6KF10, UniProtKB:O95390, UniProtKB:Q99988, MGI:MGI:88180, MGI:MGI:88182, MGI:MGI:1338027, PANTHER:PTN000218063, UniProtKB:P61812, UniProtKB:P43026, UniProtKB:P22004 Gaudet et al., 2010