Gene

ddx3xb

ID

ZDB-GENE-980526-150

Name

DEAD-box helicase 3 X-linked b

Symbol

ddx3xb Nomenclature History

Previous Names

ddx3b
etID309900.24 (1)
p110a
pl10
pl10a
wu:fb43h11
wu:fy72b06

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and RNA helicase activity. Involved in brain development. Predicted to localize to P granule and nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Fitzgerald et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddx3xb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, X-linked syndromic, Snijders Blok type	300958

Associated With ddx3xb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	ATP-dependent RNA helicase DEAD-box, conserved site	DEAD/DEAH box helicase domain	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	RNA helicase, DEAD-box type, Q motif
UniProtKB:A0A8M2BGM7 InterPro	705
UniProtKB:Q6PBB2 InterPro	688
UniProtKB:A0A8M2BG33 InterPro	719
UniProtKB:A0A8M2BG39 InterPro	702
UniProtKB:A0A8M2BG28 InterPro	704
UniProtKB:A0A8M2BG36 InterPro	721

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ddx3xb-201 (1) Ensembl	Havana	4367 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ddx3xb-203 (1) Ensembl	Havana	886 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ddx3xb-204 (1) Ensembl	Havana	1070 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ddx3b-004 (1) Ensembl	Havana	640 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ddx3b-005 (1) Ensembl	Havana	949 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ddx3b-006 (1) Ensembl	Havana	632 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ddx3b-007 (1) Ensembl	Havana	788 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations