Gene

kcnn4

ID

ZDB-GENE-131127-192

Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Symbol

kcnn4 Nomenclature History

Previous Names

si:dkeyp-84f3.3 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to localize to neuron projection; neuronal cell body; and plasma membrane. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 2. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Silic et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnn4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dehydrated hereditary stomatocytosis 2	Alliance	Dehydrated hereditary stomatocytosis 2	616689

Associated With kcnn4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004178	Calmodulin-binding domain
Domain	IPR013099	Potassium channel domain
Family	IPR015449	Potassium channel, calcium-activated, SK
Homologous_superfamily	IPR036122	SK, calmodulin-binding domain superfamily