Gene
mgmt
- ID
- ZDB-GENE-120614-1
- Name
- O-6-methylguanine-DNA methyltransferase
- Symbol
- mgmt Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; endocrine gland cancer (multiple); female reproductive organ cancer (multiple); nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR001497 | Methylated-DNA-[protein]-cysteine S-methyltransferase, active site |
Domain | IPR008332 | Methylguanine DNA methyltransferase, ribonuclease-like domain |
Domain | IPR014048 | Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding |
Homologous_superfamily | IPR036217 | Methylated DNA-protein cysteine methyltransferase, DNA binding domain |
Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Homologous_superfamily | IPR036631 | Methylated DNA-protein cysteine methyltransferase domain superfamily |
Domain Details Per Protein
Protein | Length | Methylated DNA-protein cysteine methyltransferase, DNA binding domain | Methylated DNA-protein cysteine methyltransferase domain superfamily | Methylated-DNA-[protein]-cysteine S-methyltransferase, active site | Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding | Methylguanine DNA methyltransferase, ribonuclease-like domain | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:X1WB89
|
187 | ||||||
UniProtKB:F1R3V2
|
192 |
Interactions and Pathways
No data available
Plasmids
No data available