Gene
nthl1
- ID
- ZDB-GENE-120511-4
- Name
- nth-like DNA glycosylase 1
- Symbol
- nthl1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair, DNA incision, 5'-to lesion. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial adenomatous polyposis 3 | Alliance | Familial adenomatous polyposis 3 | 616415 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000445 | Helix-hairpin-helix motif |
| Conserved_site | IPR003651 | Endonuclease III-like, iron-sulphur cluster loop motif |
| Conserved_site | IPR004036 | Endonuclease III-like, conserved site-2 |
| Domain | IPR003265 | HhH-GPD domain |
| Family | IPR030841 | Endonuclease III-like protein 1 |
| Homologous_superfamily | IPR011257 | DNA glycosylase |
| Homologous_superfamily | IPR023170 | Helix-hairpin-helix, base-excision DNA repair, C-terminal |
Domain Details Per Protein
| Protein | Length | DNA glycosylase | Endonuclease III-like, conserved site-2 | Endonuclease III-like, iron-sulphur cluster loop motif | Endonuclease III-like protein 1 | Helix-hairpin-helix, base-excision DNA repair, C-terminal | Helix-hairpin-helix motif | HhH-GPD domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QBP9
|
430 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available