Gene
alkbh8
- ID
- ZDB-GENE-100922-251
- Name
- alkB homolog 8, tRNA methyltransferase
- Symbol
- alkbh8 Nomenclature History
- Previous Names
-
- si:dkey-255n6.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity; oxidoreductase activity; and tRNA (uracil) methyltransferase activity. Predicted to be involved in oxidation-reduction process; tRNA methylation; and tRNA wobble uridine modification. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ALKBH8 (alkB homolog 8, tRNA methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 71 | Alliance | Intellectual developmental disorder, autosomal recessive 71 | 618504 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase |
| Domain | IPR013216 | Methyltransferase type 11 |
| Domain | IPR027450 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Domain | IPR034256 | ALKBH8, RNA recognition motif |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
Domain Details Per Protein
| Protein | Length | ALKBH8, RNA recognition motif | Alpha-ketoglutarate-dependent dioxygenase AlkB-like | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Methyltransferase type 11 | Nucleotide-binding alpha-beta plait domain superfamily | Oxoglutarate/iron-dependent dioxygenase | RNA-binding domain superfamily | RNA recognition motif domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P8I1
|
557 | |||||||||
|
UniProtKB:E9QB52
|
666 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
alkbh8-201
(1)
|
Havana | 2164 nt |
Interactions and Pathways
No data available
Plasmids
No data available