Gene

brwd3

ID

ZDB-GENE-100921-43

Name

bromodomain and WD repeat domain containing 3

Symbol

brwd3 Nomenclature History

Previous Names

si:dkey-237j10.3

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human BRWD3 (bromodomain and WD repeat domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brwd3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 93	Alliance	Intellectual developmental disorder, X-linked 93	300659

Associated With brwd3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001487	Bromodomain
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3B2F0 InterPro	1741
UniProtKB:A0A8M9Q1J4 InterPro	1740
UniProtKB:A0A8M3ASD3 InterPro	1742
UniProtKB:A0A8M9PQW9 InterPro	1741

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	brwd3-202 (1) Ensembl	Havana	3235 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations