Gene

kcnc3a

ID

ZDB-GENE-100901-1

Name

potassium voltage-gated channel, Shaw-related subfamily, member 3a

Symbol

kcnc3a Nomenclature History

Previous Names

kv3.3 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Exhibits voltage-gated potassium channel activity. Involved in motor neuron axon guidance. Predicted to localize to several cellular components, including dendrite membrane; neuronal cell body membrane; and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Is expressed in Purkinje cell. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnc3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 13	Alliance	Spinocerebellar ataxia 13	605259

Associated With kcnc3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR003131	Potassium channel tetramerisation-type BTB domain
Domain	IPR005821	Ion transport domain
Domain	IPR021105	Potassium channel, voltage dependent, Kv3, inactivation domain
Family	IPR003968	Potassium channel, voltage dependent, Kv
Family	IPR003974	Potassium channel, voltage dependent, Kv3
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily

Domain Details Per Protein

Protein	Length	BTB/POZ domain	Ion transport domain	Potassium channel tetramerisation-type BTB domain	Potassium channel, voltage dependent, Kv	Potassium channel, voltage dependent, Kv3	Potassium channel, voltage dependent, Kv3, inactivation domain	SKP1/BTB/POZ domain superfamily	Voltage-dependent channel domain superfamily
UniProtKB:A0A8M9PW22 InterPro	626
UniProtKB:A0A8M9P777 InterPro	666
UniProtKB:A0A8M3AQN6 InterPro	636
UniProtKB:A0A8M3B8C3 InterPro	609
UniProtKB:E1AZA4 InterPro	642
UniProtKB:E1AZA5 InterPro	659

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kcnc3a-202 (1) Ensembl	Havana	1929 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	kcnc3a-203 (1) Ensembl	Havana	2080 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-kcnc3a		kcnc3a		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations