Gene

kcnt1a

ID

ZDB-GENE-091231-1

Name

potassium sodium-activated channel subfamily T member 1a

Symbol

kcnt1a Nomenclature History

Previous Names

kcnt1

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have intracellular sodium activated potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transport. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and early infantile epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Silic et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnt1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nocturnal frontal lobe epilepsy 5	Alliance	Epilepsy nocturnal frontal lobe, 5	615005
developmental and epileptic encephalopathy 14	Alliance	Developmental and epileptic encephalopathy 14	614959

Associated With kcnt1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003929	Calcium-activated potassium channel BK, alpha subunit
Domain	IPR013099	Potassium channel domain
Family	IPR047871	Calcium-activated potassium channel slowpoke-like
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily