Gene

slc22a5

ID

ZDB-GENE-091012-1

Name

solute carrier family 22 member 5

Symbol

slc22a5 Nomenclature History

Previous Names

octn2 (1)
si:ch211-25g7.3

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Exhibits carnitine transmembrane transporter activity. Involved in carnitine transport and heme biosynthetic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Is expressed in several structures, including gill; head; liver; pleuroperitoneal region; and skeletal muscle. Orthologous to several human genes including SLC22A5 (solute carrier family 22 member 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Nilsson et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc22a5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
systemic primary carnitine deficiency disease	Alliance	Carnitine deficiency, systemic primary	212140

Associated With slc22a5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR005829	Sugar transporter, conserved site
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR005828	Major facilitator, sugar transporter-like
Family	IPR045915	Solute carrier family 22 members 4/5
Homologous_superfamily	IPR036259	MFS transporter superfamily

Domain Details Per Protein

Protein	Length	Major facilitator, sugar transporter-like	Major facilitator superfamily domain	MFS transporter superfamily	Solute carrier family 22 members 4/5	Sugar transporter, conserved site
UniProtKB:A0A8M9PJE3 InterPro	549
UniProtKB:A0A8M9PV45 InterPro	488
UniProtKB:A0A8M9PRM1 InterPro	346

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slc22a5-201 (1) Ensembl	Havana	3729 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations