ZFIN ID: ZDB-GENE-090313-71
Gene Name: DNA replication helicase/nuclease 2
Gene Symbol: dna2
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function 4 iron, 4 sulfur cluster binding IEA UniRule:UR001349773 UniProt curators
4 iron, 4 sulfur cluster binding IEA UniProtKB-KW:KW-0004 ZFIN Electronic Annotation
5'-flap endonuclease activity IBA SGD:S000001207, UniProtKB:P51530, MGI:MGI:2443732, PANTHER:PTN000094675 Gaudet et al., 2010
5'-flap endonuclease activity IEA InterPro:IPR026851 ZFIN Electronic Annotation
5'-flap endonuclease activity ISS UniProtKB:P51530 GOA et al., 2007
ATP binding IEA UniRule:UR001349773 UniProt curators
ATP binding IEA UniProtKB-KW:KW-0067 ZFIN Electronic Annotation
catalytic activity IEA UniProtKB-KW:KW-0511 ZFIN Electronic Annotation
DNA binding IEA UniRule:UR001349773 UniProt curators
DNA binding IEA UniProtKB-KW:KW-0238 ZFIN Electronic Annotation
DNA helicase activity IEA EC:3.6.4.12 ZFIN Electronic Annotation
endonuclease activity IEA UniProtKB-KW:KW-0255 ZFIN Electronic Annotation
helicase activity IEA UniProtKB-KW:KW-0347 ZFIN Electronic Annotation
hydrolase activity IEA UniProtKB-KW:KW-0378 ZFIN Electronic Annotation
iron-sulfur cluster binding IEA UniProtKB-KW:KW-0411 ZFIN Electronic Annotation
metal ion binding IEA UniRule:UR001349773 UniProt curators
metal ion binding IEA UniProtKB-KW:KW-0479 ZFIN Electronic Annotation
nuclease activity IEA UniProtKB-KW:KW-0540 ZFIN Electronic Annotation
nucleotide binding IEA UniProtKB-KW:KW-0547 ZFIN Electronic Annotation
RNA binding IBA PANTHER:PTN000094509, UniProtKB:Q9HCE1, UniProtKB:Q92900, TAIR:locus:2064158, TAIR:locus:2171007 Gaudet et al., 2010
single-stranded DNA helicase activity IEA UniRule:UR001349773 UniProt curators
single-stranded DNA helicase activity IEA InterPro:IPR026851 ZFIN Electronic Annotation
site-specific endodeoxyribonuclease activity, specific for altered base ISS UniProtKB:P51530 GOA et al., 2007
Cellular Component cytoplasm IBA SGD:S000001207, UniProtKB:P51530, PomBase:SPBC16D10.04c, PANTHER:PTN000094675 Gaudet et al., 2010
COLOCALIZES WITH gamma DNA polymerase complex ISS UniProtKB:P51530 GOA et al., 2007
mitochondrion IEA UniProtKB-KW:KW-0496 ZFIN Electronic Annotation
mitochondrion IEA UniProtKB-SubCell:SL-0173 UniProt-GOA
nuclear chromosome, telomeric region IBA SGD:S000001207, MGI:MGI:2443732, PANTHER:PTN000094675 Gaudet et al., 2010
nuclear chromosome, telomeric region IBA SGD:S000001207, MGI:MGI:2443732, PomBase:SPBC16D10.04c, PANTHER:PTN000094675 Gaudet et al., 2010
nucleus IBA SGD:S000001207, UniProtKB:P51530, UniProtKB:A0A1P8ASY1, WB:WBGene00001016, PANTHER:PTN000094675 Gaudet et al., 2010
nucleus IEA UniProtKB-KW:KW-0539 ZFIN Electronic Annotation
Biological Process base-excision repair ISS UniProtKB:P51530 GOA et al., 2007
cellular response to DNA damage stimulus IEA UniProtKB-KW:KW-0227 ZFIN Electronic Annotation
DNA repair IEA UniProtKB-KW:KW-0234 ZFIN Electronic Annotation
DNA replication IEA UniProtKB-KW:KW-0235 ZFIN Electronic Annotation
DNA replication, Okazaki fragment processing IEA UniRule:UR001349773 UniProt curators
DNA replication, Okazaki fragment processing IEA InterPro:IPR026851 ZFIN Electronic Annotation
DNA replication, removal of RNA primer ISS UniProtKB:P51530 GOA et al., 2007
metabolic process IEA UniProtKB-KW:KW-0511 ZFIN Electronic Annotation
mitochondrial DNA replication ISS UniProtKB:P51530 GOA et al., 2007
positive regulation of DNA replication ISS UniProtKB:P51530 GOA et al., 2007
replication fork reversal IBA PomBase:SPBC16D10.04c, PANTHER:PTN000094675 Gaudet et al., 2010