Gene

vhll

ID

ZDB-GENE-081022-78

Name

von Hippel-Lindau tumor suppressor like

Symbol

vhll Nomenclature History

Previous Names

vll (1)
vhl-like (1)
zgc:194223

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to be involved in protein ubiquitination. Predicted to localize to VCB complex and nucleus. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHLL (VHL like) and VHL (von Hippel-Lindau tumor suppressor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Kim et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vhll Human Ortholog

No data available

Associated With vhll Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR022772	von Hippel-Lindau disease tumour suppressor, beta/alpha domain
Domain	IPR024048	von Hippel-Lindau disease tumour suppressor, alpha domain
Domain	IPR024053	von Hippel-Lindau disease tumour suppressor, beta domain
Homologous_superfamily	IPR036208	VHL superfamily
Homologous_superfamily	IPR037139	von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
Homologous_superfamily	IPR037140	von Hippel-Lindau disease tumour suppressor, beta domain superfamily