Gene

phc1

ID

ZDB-GENE-081022-39

Name

polyhomeotic homolog 1

Symbol

phc1 Nomenclature History

Previous Names

zgc:193796

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have zinc ion binding activity. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to human PHC1 (polyhomeotic homolog 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Espanola et al., 2020

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With phc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 11	Alliance	?Microcephaly 11, primary, autosomal recessive	615414

Associated With phc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR012313	Zinc finger, FCS-type
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR038603	FCS-type zinc finger superfamily